登録情報 | データベース: PDB / ID: 8wf6 |
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タイトル | 14-3-3 zeta complexed with S559 phosphorylated peptide derived from GPIb alpha cytoplasmic domain |
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要素 | - 14-3-3 protein zeta/delta
- S559 phosphorylated peptide
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キーワード | BLOOD CLOTTING / Complex / 14-3-3 zeta / GPIb alpha |
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機能・相同性 | 機能・相同性情報
thrombin-activated receptor activity / glycoprotein Ib-IX-V complex / Enhanced binding of GP1BA variant to VWF multimer:collagen / Defective binding of VWF variant to GPIb:IX:V / synaptic target recognition / Golgi reassembly / blood coagulation, intrinsic pathway / NOTCH4 Activation and Transmission of Signal to the Nucleus / Defective F9 activation / establishment of Golgi localization ...thrombin-activated receptor activity / glycoprotein Ib-IX-V complex / Enhanced binding of GP1BA variant to VWF multimer:collagen / Defective binding of VWF variant to GPIb:IX:V / synaptic target recognition / Golgi reassembly / blood coagulation, intrinsic pathway / NOTCH4 Activation and Transmission of Signal to the Nucleus / Defective F9 activation / establishment of Golgi localization / Platelet Adhesion to exposed collagen / respiratory system process / tube formation / regulation of synapse maturation / Rap1 signalling / positive regulation of platelet activation / negative regulation of protein localization to nucleus / megakaryocyte development / KSRP (KHSRP) binds and destabilizes mRNA / GP1b-IX-V activation signalling / regulation of blood coagulation / Platelet Aggregation (Plug Formation) / Regulation of localization of FOXO transcription factors / Interleukin-3, Interleukin-5 and GM-CSF signaling / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / protein targeting / regulation of ERK1 and ERK2 cascade / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / cellular response to glucose starvation / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / fibrinolysis / RHO GTPases activate PKNs / Intrinsic Pathway of Fibrin Clot Formation / negative regulation of TORC1 signaling / release of sequestered calcium ion into cytosol / ERK1 and ERK2 cascade / Transcriptional and post-translational regulation of MITF-M expression and activity / extracellular matrix / lung development / Deactivation of the beta-catenin transactivating complex / protein sequestering activity / negative regulation of innate immune response / hippocampal mossy fiber to CA3 synapse / Negative regulation of NOTCH4 signaling / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / regulation of protein stability / platelet activation / cell morphogenesis / blood coagulation / melanosome / intracellular protein localization / blood microparticle / vesicle / angiogenesis / protein phosphatase binding / DNA-binding transcription factor binding / transmembrane transporter binding / cell surface receptor signaling pathway / protein phosphorylation / cell adhesion / cadherin binding / protein domain specific binding / external side of plasma membrane / focal adhesion / ubiquitin protein ligase binding / protein kinase binding / negative regulation of apoptotic process / glutamatergic synapse / cell surface / negative regulation of transcription by RNA polymerase II / signal transduction / extracellular space / RNA binding / extracellular exosome / nucleoplasm / identical protein binding / nucleus / membrane / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Leucine rich repeat N-terminal domain / Leucine-rich repeat N-terminal domain / Leucine rich repeat N-terminal domain / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Leucine-rich repeats, bacterial type / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein ...Leucine rich repeat N-terminal domain / Leucine-rich repeat N-terminal domain / Leucine rich repeat N-terminal domain / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Leucine-rich repeats, bacterial type / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily類似検索 - ドメイン・相同性 SUCCINIC ACID / Platelet glycoprotein Ib alpha chain / 14-3-3 protein zeta/delta類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.47 Å |
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データ登録者 | Shu, Z.M. / Zhou, A.W. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | | 中国 |
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引用 | ジャーナル: To Be Published タイトル: Cryo-EM structure of GPIb-IX Complex 著者: Shu, Z.M. / Zhou, A.W. |
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履歴 | 登録 | 2023年9月19日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2024年9月25日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年10月9日 | Group: Derived calculations / Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature ...pdbx_entry_details / pdbx_modification_feature / pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop Item: _pdbx_entry_details.has_protein_modification |
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