Entry Database : PDB / ID : 8voh Structure visualization Downloads & linksTitle HADDOCK models of human alphaM I-domain bound to the the N-terminal domain of the cytokine pleiotrophin ComponentsIntegrin alpha-M Pleiotrophin DetailsKeywords CELL ADHESION / integrin / Mac-1 / pleiotrophinFunction / homology Function and homology informationFunction Domain/homology Component
dendrite regeneration / ossification involved in bone remodeling / ectodermal cell differentiation / cell surface receptor protein tyrosine phosphatase signaling pathway / leukocyte chemotaxis involved in inflammatory response / positive regulation of prostaglandin-E synthase activity / positive regulation of neutrophil degranulation / response to curcumin / integrin alphaM-beta2 complex / chondroitin sulfate binding ... dendrite regeneration / ossification involved in bone remodeling / ectodermal cell differentiation / cell surface receptor protein tyrosine phosphatase signaling pathway / leukocyte chemotaxis involved in inflammatory response / positive regulation of prostaglandin-E synthase activity / positive regulation of neutrophil degranulation / response to curcumin / integrin alphaM-beta2 complex / chondroitin sulfate binding / positive regulation of microglial cell mediated cytotoxicity / regulation of stem cell population maintenance / response to Gram-positive bacterium / regulation of endothelial cell migration / dendrite arborization / MDK and PTN in ALK signaling / positive regulation of stem cell differentiation / complement component C3b binding / vertebrate eye-specific patterning / response to auditory stimulus / complement-mediated synapse pruning / Toll Like Receptor 4 (TLR4) Cascade / negative regulation of dopamine metabolic process / cell-cell adhesion via plasma-membrane adhesion molecules / tissue regeneration / positive regulation of leukocyte chemotaxis / complement receptor mediated signaling pathway / positive regulation of ossification / positive regulation of hepatocyte proliferation / positive regulation of dendrite development / heterotypic cell-cell adhesion / integrin complex / cargo receptor activity / protein phosphatase inhibitor activity / regulation of myelination / cell adhesion mediated by integrin / regulation of hemopoiesis / negative regulation of neuroblast proliferation / Signaling by ALK / positive regulation of oligodendrocyte differentiation / oogenesis / phagocytosis, engulfment / positive regulation of axon regeneration / bone mineralization / receptor clustering / amyloid-beta clearance / plasma membrane raft / tertiary granule membrane / positive regulation of cell division / decidualization / negative regulation of long-term synaptic potentiation / estrous cycle / positive regulation of protein targeting to membrane / Integrin cell surface interactions / positive regulation of bone mineralization / specific granule membrane / response to mechanical stimulus / positive regulation of superoxide anion generation / forebrain development / heat shock protein binding / receptor-mediated endocytosis / cell-matrix adhesion / learning / molecular function activator activity / response to ischemia / integrin-mediated signaling pathway / Cell surface interactions at the vascular wall / cell-cell adhesion / microglial cell activation / growth factor activity / regulation of synaptic plasticity / Schaffer collateral - CA1 synapse / memory / positive regulation of neuron projection development / integrin binding / response to estradiol / nervous system development / heparin binding / amyloid-beta binding / carbohydrate binding / Interleukin-4 and Interleukin-13 signaling / cell adhesion / external side of plasma membrane / innate immune response / positive regulation of cell population proliferation / Neutrophil degranulation / protein kinase binding / cell surface / endoplasmic reticulum / protein-containing complex / extracellular space / extracellular exosome / extracellular region / metal ion binding / plasma membrane Similarity search - Function Pleiotrophin/Midkine heparin-binding growth factor, conserved site / PTN/MK heparin-binding protein family signature 1. / PTN/MK heparin-binding protein family signature 2. / Midkine heparin-binding growth factor / Pleiotrophin/Midkine, N-terminal domain / Pleiotrophin/Midkine, C-terminal domain / Pleiotrophin/Midkine disulphide-rich domain superfamily / Pleiotrophin/Midkine, N-terminal domain superfamily / Pleiotrophin/Midkine, C-terminal domain superfamily / PTN/MK heparin-binding protein family, C-terminal domain ... Pleiotrophin/Midkine heparin-binding growth factor, conserved site / PTN/MK heparin-binding protein family signature 1. / PTN/MK heparin-binding protein family signature 2. / Midkine heparin-binding growth factor / Pleiotrophin/Midkine, N-terminal domain / Pleiotrophin/Midkine, C-terminal domain / Pleiotrophin/Midkine disulphide-rich domain superfamily / Pleiotrophin/Midkine, N-terminal domain superfamily / Pleiotrophin/Midkine, C-terminal domain superfamily / PTN/MK heparin-binding protein family, C-terminal domain / PTN/MK heparin-binding protein family, N-terminal domain / Pleiotrophin / midkine family / : / Integrin alpha-X-like, Ig-like domain 3 / Integrin alpha cytoplasmic region / Integrin alpha-2 / Integrin alpha Ig-like domain 1 / : / Integrin alpha Ig-like domain 2 / Integrin alpha chain / Integrin alpha beta-propellor / Integrin alpha chain, C-terminal cytoplasmic region, conserved site / Integrins alpha chain signature. / FG-GAP repeat profile. / Integrin alpha (beta-propellor repeats). / FG-GAP repeat / FG-GAP repeat / Integrin alpha, N-terminal / Integrin domain superfamily / von Willebrand factor type A domain / von Willebrand factor (vWF) type A domain / VWFA domain profile. / von Willebrand factor, type A / von Willebrand factor A-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method SOLUTION NMR / simulated annealing DetailsAuthors Wang, X. / Nguyen, H. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM118518 United States National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) HL063199 United States
CitationJournal : To Be Published Title : NMR structure of alphaM I-domain of integrin Mac-1 in complex with the Cytokine PleiotrophinAuthors : Wang, X. / Nguyen, H. History Deposition Jan 15, 2024 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 15, 2024 Provider : repository / Type : Initial release