PDB-8vkb: Crystal structure of Plasmodium vivax glycylpeptide N-tetradecano...

ID or keywords:

Entry

Database: PDB / ID: 8vkb

Title

Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 10b

Components

Glycylpeptide N-tetradecanoyltransferase

Keywords

TRANSFERASE / Enzyme / Inhibitor / Complex / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / SSGCID

Function / homology

Function and homology information

glycylpeptide N-tetradecanoyltransferase / glycylpeptide N-tetradecanoyltransferase activity / metal ion binding / cytoplasm
Similarity search - Function

Biological species

Plasmodium vivax Sal-1 (eukaryote)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.43 Å

Authors

Fenwick, M.K. / Staker, B.L. / Phan, I.Q. / Early, J. / Myler, P.J. / Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Funding support

United States, 2items

Organization	Grant number	Country
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)	R01AI155536	United States
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)	75N93022C00036	United States

Citation

Journal: J.Med.Chem. / Year: 2024
Title: Exploring Subsite Selectivity within Plasmodium vivax N -Myristoyltransferase Using Pyrazole-Derived Inhibitors.
Authors: Rodriguez-Hernandez, D. / Fenwick, M.K. / Zigweid, R. / Sankaran, B. / Myler, P.J. / Sunnerhagen, P. / Kaushansky, A. / Staker, B.L. / Grotli, M.

History

Deposition	Jan 8, 2024	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Jul 17, 2024	Provider: repository / Type: Initial release

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	8vkb.cif.gz	877.1 KB	Display	PDBx/mmCIF format
PDB format	pdb8vkb.ent.gz		Display	PDB format
PDBx/mmJSON format	8vkb.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/vk/8vkb ftp://data.pdbj.org/pub/pdb/validation_reports/vk/8vkb	HTTPS FTP

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Related structure data

Related structure data	8vkaC C: citing same article (ref.)
Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#146 - Feb 2012 Aminoglycoside Antibiotics similarity (1) #97 - Jan 2008 Circadian Clock Proteins similarity (1)

Deposited unit

A: Glycylpeptide N-tetradecanoyltransferase

B: Glycylpeptide N-tetradecanoyltransferase

C: Glycylpeptide N-tetradecanoyltransferase

hetero molecules

141 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Glycylpeptide N-tetradecanoyltransferase

hetero molecules

defined by author&software
47.1 kDa, 1 polymers

2

B: Glycylpeptide N-tetradecanoyltransferase

hetero molecules

defined by author&software
47.2 kDa, 1 polymers

3

C: Glycylpeptide N-tetradecanoyltransferase

hetero molecules

defined by author&software
47 kDa, 1 polymers

Unit cell

Length a, b, c (Å)	57.366, 119.781, 176.883
Angle α, β, γ (deg.)	90.000, 90.000, 90.000
Int Tables number	19
Space group name H-M	P2₁2₁2₁
Space group name Hall	P2ac2ab
Symmetry operation	#1: x,y,z #2: x+1/2,-y+1/2,-z #3: -x,y+1/2,-z+1/2 #4: -x+1/2,-y,z+1/2

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Protein , 1 types, 3 molecules ABC

#1: Protein	Glycylpeptide N-tetradecanoyltransferase Mass: 45100.566 Da / Num. of mol.: 3 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Plasmodium vivax Sal-1 (eukaryote) / Gene: PVX_085815 / Plasmid: pET11a / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: A5K1A2

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Non-polymers , 7 types, 649 molecules

#2: Chemical	ChemComp-MYA / TETRADECANOYL-COA / MYRISTOYL-COA Mass: 977.890 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C₃₅H₆₂N₇O₁₇P₃S / Feature type: SUBJECT OF INVESTIGATION
#3: Chemical	ChemComp-A1AB8 / {1,5-dimethyl-4-[2-({(1P)-1-[2-(piperazin-1-yl)pyridin-4-yl]naphthalen-2-yl}oxy)ethyl]-1H-pyrazol-3-yl}(morpholin-4-yl)methanone Mass: 540.656 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C₃₁H₃₆N₆O₃ / Feature type: SUBJECT OF INVESTIGATION
#4: Chemical	ChemComp-CL / CHLORIDE ION Mass: 35.453 Da / Num. of mol.: 18 / Source method: obtained synthetically / Formula: Cl
#5: Chemical	ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL Mass: 92.094 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C₃H₈O₃
#6: Chemical	ChemComp-1PE / PENTAETHYLENE GLYCOL / PEG400 Mass: 238.278 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₁₀H₂₂O₆ / Comment: precipitant*YM
#7: Chemical	ChemComp-P6G / HEXAETHYLENE GLYCOL / POLYETHYLENE GLYCOL PEG400 Mass: 282.331 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₁₂H₂₆O₇ / Comment: precipitant*YM
#8: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 620 / Source method: isolated from a natural source / Formula: H₂O

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Details

Has ligand of interest	Y

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.25 Å³/Da / Density % sol: 45.23 %
Crystal grow	Temperature: 296 K / Method: vapor diffusion, sitting drop Details: 0.2 M magnesium chloride, 0.1 M Tris, pH 8.5, and 20% PEG 8000

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Data collection

Diffraction	Mean temperature: 100 K / Serial crystal experiment: N
Diffraction source	Source: SYNCHROTRON / Site: ALS / Beamline: 8.2.2 / Wavelength: 1.00004 Å
Detector	Type: ADSC QUANTUM 315 / Detector: CCD / Date: Jul 1, 2022
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 1.00004 Å / Relative weight: 1
Reflection	Resolution: 2.43→48.13 Å / Num. obs: 46174 / % possible obs: 99.1 % / Redundancy: 3.6 % / B_iso Wilson estimate: 28.46 Å² / CC_1/2: 0.985 / R_merge(I) obs: 0.159 / R_pim(I) all: 0.096 / R_rim(I) all: 0.186 / Χ²: 0.59 / Net I/σ(I): 5.3 / Num. measured all: 166469
Reflection shell	Resolution: 2.43→2.52 Å / % possible obs: 99.8 % / Redundancy: 3.7 % / R_merge(I) obs: 0.696 / Num. measured all: 16760 / Num. unique obs: 4540 / CC_1/2: 0.559 / R_pim(I) all: 0.424 / R_rim(I) all: 0.82 / Χ²: 0.56 / Net I/σ(I) obs: 1.6

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Processing

Software

Name	Version	Classification
XDS		data reduction
PHENIX	1.20.1_4487	refinement
Aimless		data scaling
PHASER		phasing
Coot		model building
PDB_EXTRACT		data extraction

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT / Resolution: 2.43→48.13 Å / SU ML: 0.2979 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 21.5578
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2

	R_factor	Num. reflection	% reflection
R_free	0.2326	2347	5.09 %
R_work	0.1849	43794	-
obs	0.1873	46141	98.46 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL

Displacement parameters

B_iso mean: 31.48 Å²

Refinement step

Cycle: LAST / Resolution: 2.43→48.13 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	9485	0	380	620	10485

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.0022	10345
X-RAY DIFFRACTION	f_angle_d	0.471	14054
X-RAY DIFFRACTION	f_chiral_restr	0.0415	1488
X-RAY DIFFRACTION	f_plane_restr	0.0029	1741
X-RAY DIFFRACTION	f_dihedral_angle_d	18.5134	3834

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
2.43-2.48	0.2956	157	0.238	2569	X-RAY DIFFRACTION	99.78
2.48-2.53	0.2806	114	0.2355	2569	X-RAY DIFFRACTION	99.7
2.53-2.59	0.286	154	0.2331	2585	X-RAY DIFFRACTION	99.78
2.59-2.66	0.2986	139	0.2438	2556	X-RAY DIFFRACTION	99.74
2.66-2.73	0.2995	140	0.2354	2590	X-RAY DIFFRACTION	99.82
2.73-2.81	0.2915	144	0.223	2551	X-RAY DIFFRACTION	99.89
2.81-2.9	0.2714	128	0.2191	2591	X-RAY DIFFRACTION	99.89
2.9-3	0.3049	123	0.2122	2626	X-RAY DIFFRACTION	99.96
3-3.12	0.2361	150	0.2016	2545	X-RAY DIFFRACTION	99.96
3.12-3.27	0.247	132	0.1876	2610	X-RAY DIFFRACTION	99.93
3.27-3.44	0.2344	159	0.1761	2591	X-RAY DIFFRACTION	99.78
3.44-3.65	0.2131	137	0.1734	2584	X-RAY DIFFRACTION	99.05
3.65-3.94	0.2251	129	0.1587	2573	X-RAY DIFFRACTION	97.51
3.94-4.33	0.1626	144	0.1475	2574	X-RAY DIFFRACTION	98.19
4.33-4.96	0.1859	147	0.1326	2559	X-RAY DIFFRACTION	96.95
4.96-6.24	0.1926	138	0.1716	2578	X-RAY DIFFRACTION	95.8
6.24-48.13	0.2382	112	0.1847	2543	X-RAY DIFFRACTION	89.12

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	2.52348901256	-1.38819076423	-2.05968511701	2.19708165813	3.1587464986	4.90793752772	0.169188597277	-0.442703702853	0.191850191329	-0.0023392287387	0.115846819219	0.0212783823907	-0.21981639755	0.313331258548	-0.284729864821	0.170895555773	-0.0522896345334	-0.0163588834952	0.288287882917	-0.0420889478242	0.327631155025	43.3813844341	33.9796028428	26.0852722698
2	3.94778545249	-0.192678459246	-1.14695113861	1.98525269425	-0.418798815812	2.2545435695	0.105572853266	0.0256312488119	-0.072863133173	-0.176491595368	-0.0348178146361	0.0361230717685	0.325237459466	0.129164499969	-0.0609630706389	0.261924309042	0.0197150639331	-0.0264189040153	0.126901641116	-0.0308399855795	0.219494130292	32.8880386511	13.7939664538	11.2628956644
3	1.2946501628	-1.1587375241	-0.547513812168	2.19265345249	2.24704993741	2.87742956438	0.0855531490398	0.103487238341	0.0317790970491	-0.225814020233	0.0966406022697	-0.294521544116	-0.0400774338686	0.104769264741	-0.15509547682	0.140104504963	-0.017995999467	0.0249479212502	0.196948117292	0.0295529440785	0.196322924787	34.9825146615	20.747208665	8.51310043189
4	2.12962768481	-2.27498083231	0.450145614029	7.63580947911	-0.466279860463	0.114278253902	0.0291338516895	-0.0858311775735	0.169213336865	0.272774686614	-0.149160041398	-0.148545452891	-0.0389717071265	-0.0372181851211	0.108779773557	0.245780620656	0.0267046503004	0.0681568394999	0.188863396297	0.00919349189704	0.170271779595	35.830595918	22.3003821362	18.5525608473
5	3.44488991277	0.179676387373	-2.4002766944	6.35634669696	-3.45088629771	3.9216526303	0.107256926949	0.0986771299126	0.0751747755659	-0.172648340866	-0.0830573716761	-0.0152377234128	0.129532925549	0.115650580719	-0.0158106115428	0.195538999095	-0.030249450228	-0.0523474407306	0.152403092647	-0.0391508006165	0.187092604006	40.6126701674	27.6306098638	14.0543067828
6	0.526604798731	0.548399016838	-0.384841256622	0.68786510083	-0.218683786477	0.601506429648	-0.0729142547305	-0.133543401509	0.00731503409713	0.0336906796157	0.0253530219068	0.0420490465535	0.0481111373408	-0.117237240709	0.040052175645	0.272229288403	0.00742952931527	0.0114149483181	0.223325468107	-0.00226863991054	0.311830680444	9.87561517329	16.6165118288	28.3742219301
7	2.54793576349	-0.375193451676	1.15980250753	1.26465849419	2.41184316754	6.02356943035	-0.0637560657485	0.0981566796903	-0.00227065030952	-0.127324239948	-0.0130424092239	0.0792816443568	-0.343975054058	-0.0251167628781	0.0725593829361	0.192709309781	-0.051125593036	0.0207287457464	0.153963865184	0.0514272124101	0.245974650542	16.7127138645	34.1644038035	12.3327495117
8	2.79492249801	-1.0722718163	-0.535348643382	4.20594224859	1.05659441567	1.84059762726	-0.0533305379906	0.188611168553	-0.0522102064499	0.176147693436	-0.0191446669553	0.232585014547	0.0476039535072	-0.097341032939	0.0556564104799	0.162077555981	-0.0269270585778	-0.0155914453901	0.173785346529	0.0182873469909	0.124527950512	9.7847042997	23.0693951022	21.2405651887
9	8.1919904853	1.69773938825	-2.35780769378	0.627466186899	-0.710959855126	1.60431469102	-0.01636838849	-0.29845666741	0.368611087946	-0.00614939673118	-0.0419431173731	0.12976435233	0.0542169145792	0.0974986286936	0.0581000991505	0.21616822629	-0.023050176314	-0.0332280615138	0.132701001969	0.00622459821776	0.202669905408	26.7192412786	29.2778215465	27.8528729475
10	2.51332551198	-0.642877703498	-2.00092088839	0.472914575393	1.75790958884	6.58550150087	-0.146091152077	-0.0102375920182	0.0142163628168	-0.015665355323	-0.0278666489296	0.0518945089906	0.466163795782	0.0122050984227	0.161676582033	0.195609261418	-0.0260647065983	-0.0479812120976	0.235932490196	-0.0738706105449	0.318460788832	-3.52899397149	42.0449029204	39.7878649544
11	4.21400898125	-0.963696703851	0.595460790837	2.13805722062	-1.23751598751	2.03217367818	0.112863650498	-0.250743717471	-0.0736137689337	0.0424499077293	0.0083587326926	-0.0965344652869	0.105229675622	0.0892808223158	-0.0985875629485	0.199510198857	-0.0448439373209	0.0101879456189	0.217377578279	-0.0398584853009	0.247174383608	6.21717483146	46.6307002146	64.6352862621
12	1.45714458593	-0.0148584910459	-0.948121530966	0.425479130644	-1.02590470575	3.91751902564	0.0750510651703	-0.215483589011	0.104221221632	0.176568739163	-0.0127756286881	-0.0944889429533	-0.421336756665	0.0135811546819	-0.0818179465571	0.26736781058	0.00366158947825	-0.0261007541491	0.198418359906	-0.0240968709561	0.267810774089	4.69300965662	52.1803249939	59.5597512589
13	1.00902189273	-0.0126788705493	-0.0722422174931	1.74203426126	-1.45070514432	2.1366214148	0.00721805650497	-0.0171265226386	-0.0461356636831	0.105268490221	-0.0218583095981	-0.120776128289	0.000320272737214	0.0242994893764	0.0209330597639	0.160520912372	-0.0141130034525	-0.024249048044	0.168202711632	-0.0274628908948	0.177102124656	1.55516139429	47.3416746413	52.1785807403
14	4.60303454216	-2.59046044973	2.84550178274	2.39623944955	-0.826963762858	2.91959229953	0.176803666866	-0.00913852085518	-0.736312535952	0.0911771398127	0.0311569381877	0.200309144418	0.329850843387	0.233738003267	-0.20521818602	0.218305354092	-0.00710237371557	0.0598066891334	0.234698435572	0.035204978073	0.364977179746	22.8678034008	28.3019978603	54.3516627953
15	0.42889564502	0.0198595962005	0.647862498153	8.6678192946	-0.987707656844	1.1043185928	-0.0516898942116	0.0330669823624	-0.27988561152	-0.0326653190152	0.00367951186096	-0.624446266998	0.120446649633	0.183369247402	0.053271587376	0.212793948578	-0.000138559009967	0.0662647688904	0.273857705211	0.0170029123419	0.417524199244	39.5887623589	37.7102155381	54.1448480954
16	2.26339155466	-0.157602167495	0.101517290014	3.67066901875	0.389593160325	6.41356317862	0.00376383976139	-0.078195371707	0.347776189457	-0.245407297422	-0.0567172432501	-0.0590515477358	-0.159705936502	0.0611112981035	0.0887176981365	0.122936135343	0.00320155768583	-0.0135725604236	0.127422761674	0.00967201632576	0.284987478453	23.2666321919	54.9682807242	46.0303412834
17	2.47330839188	0.399737508194	-0.750324818919	3.19821506087	-0.597472638103	2.90360868157	0.0546182348362	-0.134347413923	-0.141792984396	-0.027424249969	-0.078133467015	-0.07747830769	0.059271303774	0.219260998489	0.0283940277091	0.110167499748	0.0123065555909	-0.0329456074875	0.188427112987	0.00813469210818	0.196600144354	29.5238319457	41.2822299299	51.6701891528
18	2.91134483451	-1.63228613031	-1.94589581378	3.40581900611	0.253251828656	1.58380984242	-0.0362853911864	0.0405510697846	0.0951976788213	0.072769173285	-0.0412326219936	-0.128471888908	0.0863413581838	-0.0845375029721	0.0938187127619	0.23755373458	-0.0362708763089	-0.0594160934744	0.214857552923	-0.0797185299818	0.243303916029	10.1234656965	41.5710960384	41.9178394295
19	4.82571511778	2.49976581754	-1.25566295862	4.01550146856	-2.66491308694	1.81805270557	-0.253602303416	0.264599623908	-0.305780905783	-0.528716349121	0.160190502403	-0.326033297722	0.554178144444	-0.188023545841	0.080268487582	0.445366418169	-0.00651774373979	0.00834065167071	0.260388557739	-0.00143919042464	0.505065309204	21.963078572	59.1726322697	13.1093998236
20	3.19463666071	0.893954849483	-0.255134662239	2.07296401543	-1.4817646947	2.20793437029	-0.0289215831132	0.0343535250041	0.352081428625	0.0386759547889	-0.0254562190172	0.0235450803462	-0.194803528983	-0.00747513360718	0.0553376006012	0.252075394042	0.00576878513446	0.0288335743772	0.165268861266	-0.0381217574056	0.235456784201	12.2800073094	82.3978930785	7.67558113009
21	1.26396975882	0.58863262758	0.823335599473	1.02232547845	-0.187571888433	1.0366890715	0.00154033493425	0.0784034422105	-0.148519477161	-0.0912024622038	-0.0596167982217	-0.0669354653671	0.124535342982	0.0708438032043	0.0476808966177	0.219612640784	0.0358089582434	0.0236695528128	0.180797731925	-0.0415437195212	0.254274213633	13.3797747374	69.4012347505	8.58451402486
22	1.66155319751	2.81651257887	2.40759749621	5.22212534982	3.68273004473	5.73090262758	-0.288849396186	0.586808263166	-0.258652396838	-0.354505394321	0.23516750629	-0.421866049799	0.157355858573	0.894864417643	0.0605723303361	0.298400590815	0.0313113764971	-0.0124098620843	0.462383248708	0.116933250834	0.426038727041	-11.8724780229	68.1231802832	-12.006007124
23	3.10156054158	0.139445126141	0.324553479707	1.96695506216	-0.498439902389	1.80419017928	0.00514985059623	-0.00138325305845	-0.0760425855498	-0.0945731045359	0.0324874687566	0.0802789707135	0.0642060583825	-0.165727223619	-0.0408613734714	0.201796713924	0.0122215052747	0.0166959625149	0.163677608823	-0.00594171734348	0.198291224714	-10.71168601	69.3962356856	10.5507885349
24	5.15892102691	2.22048734938	1.40995194684	1.25551107868	1.33187973201	4.40793351033	0.288045913603	0.0642088188474	-0.441671468278	-0.296895078218	-0.119388403044	-0.211574974649	0.167905161294	0.130060554854	-0.157984200456	0.278309703863	0.0426113483694	0.0346107752776	0.122916682401	-0.00298302381356	0.289636760254	8.04146951776	60.4283517513	11.1446323568

Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

ID	Refine TLS-ID	Selection details	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	1	chain 'A' and (resid 27 through 59 )	A	A	27 - 59	1 - 33
2	2	chain 'A' and (resid 60 through 116 )	A	A	60 - 116	34 - 90
3	3	chain 'A' and (resid 117 through 150 )	A	A	117 - 150	91 - 124
4	4	chain 'A' and (resid 151 through 174 )	A	A	151 - 174	125 - 148
5	5	chain 'A' and (resid 175 through 198 )	A	A	175 - 198	149 - 172
6	6	chain 'A' and (resid 199 through 257 )	A	A	199 - 257	173 - 231
7	7	chain 'A' and (resid 258 through 296 )	A	A	258 - 296	232 - 270
8	8	chain 'A' and (resid 297 through 379 )	A	A	297 - 379	271 - 353
9	9	chain 'A' and (resid 380 through 410 )	A	A	380 - 410	354 - 384
10	10	chain 'B' and (resid 27 through 59 )	B	J	27 - 59	1 - 33
11	11	chain 'B' and (resid 60 through 116 )	B	J	60 - 116	34 - 90
12	12	chain 'B' and (resid 117 through 150 )	B	J	117 - 150	91 - 124
13	13	chain 'B' and (resid 151 through 198 )	B	J	151 - 198	125 - 172
14	14	chain 'B' and (resid 199 through 234 )	B	J	199 - 234	173 - 208
15	15	chain 'B' and (resid 235 through 257 )	B	J	235 - 257	209 - 231
16	16	chain 'B' and (resid 258 through 296 )	B	J	258 - 296	232 - 270
17	17	chain 'B' and (resid 297 through 386 )	B	J	297 - 386	271 - 360
18	18	chain 'B' and (resid 387 through 410 )	B	J	387 - 410	361 - 384
19	19	chain 'C' and (resid 26 through 59 )	C	W	26 - 59	1 - 34
20	20	chain 'C' and (resid 60 through 150 )	C	W	60 - 150	35 - 125
21	21	chain 'C' and (resid 151 through 215 )	C	W	151 - 215	126 - 190
22	22	chain 'C' and (resid 216 through 241 )	C	W	216 - 241	191 - 216
23	23	chain 'C' and (resid 242 through 386 )	C	W	242 - 386	217 - 361
24	24	chain 'C' and (resid 387 through 410 )	C	W	387 - 410	362 - 385

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