登録情報 データベース : PDB / ID : 8v52 構造の表示 ダウンロードとリンクタイトル Crystal structure of 2A10 Fab bound to Human TGF-beta3 要素2A10 Fab Heavy Chain 2A10 Fab Light chain Transforming growth factor beta-3 詳細キーワード CYTOKINE/IMMUNE SYSTEM / TGF beta / 2A10 / complex / fab / CYTOKINE / CYTOKINE-IMMUNE SYSTEM complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
uterine wall breakdown / detection of hypoxia / frontal suture morphogenesis / embryonic neurocranium morphogenesis / type III transforming growth factor beta receptor binding / positive regulation of tight junction disassembly / negative regulation of macrophage cytokine production / secondary palate development / response to laminar fluid shear stress / type II transforming growth factor beta receptor binding ... uterine wall breakdown / detection of hypoxia / frontal suture morphogenesis / embryonic neurocranium morphogenesis / type III transforming growth factor beta receptor binding / positive regulation of tight junction disassembly / negative regulation of macrophage cytokine production / secondary palate development / response to laminar fluid shear stress / type II transforming growth factor beta receptor binding / type I transforming growth factor beta receptor binding / mammary gland development / cell-cell junction organization / transforming growth factor beta binding / digestive tract development / face morphogenesis / odontogenesis / Molecules associated with elastic fibres / positive regulation of filopodium assembly / lung alveolus development / TGF-beta receptor signaling activates SMADs / negative regulation of vascular associated smooth muscle cell proliferation / positive regulation of SMAD protein signal transduction / inner ear development / positive regulation of cell division / ECM proteoglycans / positive regulation of collagen biosynthetic process / positive regulation of epithelial to mesenchymal transition / salivary gland morphogenesis / positive regulation of stress fiber assembly / T-tubule / transforming growth factor beta receptor signaling pathway / platelet alpha granule lumen / cytokine activity / response to progesterone / female pregnancy / positive regulation of protein secretion / negative regulation of transforming growth factor beta receptor signaling pathway / growth factor activity / response to estrogen / Platelet degranulation / regulation of cell population proliferation / collagen-containing extracellular matrix / in utero embryonic development / negative regulation of neuron apoptotic process / positive regulation of MAPK cascade / response to hypoxia / positive regulation of apoptotic process / negative regulation of cell population proliferation / intracellular membrane-bounded organelle / neuronal cell body / positive regulation of cell population proliferation / protein-containing complex binding / positive regulation of DNA-templated transcription / cell surface / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / identical protein binding / plasma membrane 類似検索 - 分子機能 Transforming growth factor beta-3 / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain ... Transforming growth factor beta-3 / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine-knot cytokine 類似検索 - ドメイン・相同性 Transforming growth factor beta-3 proprotein 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.5 Å 詳細データ登録者 Yin, J. / Lupardus, P.J. 資金援助 1件 詳細 詳細を隠す組織 認可番号 国 F. Hoffmann-La Roche LTD
引用ジャーナル : Med / 年 : 2024タイトル : Isoform-selective TGF-beta 3 inhibition for systemic sclerosis.著者: Sun, T. / Vander Heiden, J.A. / Gao, X. / Yin, J. / Uttarwar, S. / Liang, W.C. / Jia, G. / Yadav, R. / Huang, Z. / Mitra, M. / Halpern, W. / Bender, H.S. / Brightbill, H.D. / Wu, Y. / ... 著者 : Sun, T. / Vander Heiden, J.A. / Gao, X. / Yin, J. / Uttarwar, S. / Liang, W.C. / Jia, G. / Yadav, R. / Huang, Z. / Mitra, M. / Halpern, W. / Bender, H.S. / Brightbill, H.D. / Wu, Y. / Lupardus, P. / Ramalingam, T. / Arron, J.R. 履歴 登録 2023年11月30日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2024年4月10日 Provider : repository / タイプ : Initial release