Entry | Database: PDB / ID: 8uro |
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Title | Crystal structure of IgG1-Fc fragment (E382S) in complex with Corynebacterial ENGase CU43 (D187A-E189A) |
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Components | - Corynebacterial protease CP40
- Immunoglobulin gamma-1 heavy chain
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Keywords | IMMUNE SYSTEM / IgG1-Fc / CU43 / Endoglycosidase / IgG-specific |
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Function / homology | Function and homology information
: / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set ...: / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like foldSimilarity search - Domain/homology |
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Biological species | Corynebacterium ulcerans (bacteria)
Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.62 Å |
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Authors | Sastre, D.E. / Sultana, N. / Sundberg, E.J. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01AI149297 | United States |
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Citation | Journal: Nat Commun / Year: 2025Title: The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases. Authors: Sastre, D.E. / Bournazos, S. / Huliciak, M. / Grace, B.A.C. / Boder, E.J. / Du, J. / Sultana, N. / Azzam, T. / Brown, T.J. / Flowers, M.W. / Lollar, P. / Xu, T. / Chernova, T.A. / Keith, A.D. ...Authors: Sastre, D.E. / Bournazos, S. / Huliciak, M. / Grace, B.A.C. / Boder, E.J. / Du, J. / Sultana, N. / Azzam, T. / Brown, T.J. / Flowers, M.W. / Lollar, P. / Xu, T. / Chernova, T.A. / Keith, A.D. / Keen, M. / Saltzman, A. / Martinez Gascuena, A. / Trastoy, B. / Guerin, M.E. / Frank, F. / Ortlund, E.A. / Ravetch, J.V. / Sundberg, E.J. |
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History | Deposition | Oct 26, 2023 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Oct 30, 2024 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 16, 2025 | Group: Database references / Category: citation / citation_author |
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