登録情報 データベース : PDB / ID : 8ucb 構造の表示 ダウンロードとリンクタイトル IRAK4 in complex with compound 8 要素Interleukin-1 receptor-associated kinase 4 詳細 キーワード TRANSFERASE/INHIBITOR / kinase / TRANSFERASE / TRANSFERASE-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding ... IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding / MyD88-dependent toll-like receptor signaling pathway / interleukin-1-mediated signaling pathway / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / toll-like receptor 4 signaling pathway / toll-like receptor signaling pathway / extrinsic component of plasma membrane / JNK cascade / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / positive regulation of smooth muscle cell proliferation / cytokine-mediated signaling pathway / Interleukin-1 signaling / PIP3 activates AKT signaling / kinase activity / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / cellular response to lipopolysaccharide / positive regulation of canonical NF-kappaB signal transduction / endosome membrane / non-specific serine/threonine protein kinase / intracellular signal transduction / phosphorylation / innate immune response / protein serine kinase activity / protein serine/threonine kinase activity / protein kinase binding / cell surface / magnesium ion binding / extracellular space / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Interleukin-1 receptor-associated kinase 4 / IRAK4, Death domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性 : / Interleukin-1 receptor-associated kinase 4 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.85 Å 詳細データ登録者 Metrick, C.M. / Chodaparambil, J.V. 資金援助 1件 詳細 詳細を隠す 引用ジャーナル : J.Med.Chem. / 年 : 2024タイトル: The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)- N -(6-methylpyrazolo[1,5- a ]pyrimidin-3-yl)imidazo[1,2- a ]pyrimidine-6-carboxamide (BIO-7488), a Potent, ... タイトル : The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)- N -(6-methylpyrazolo[1,5- a ]pyrimidin-3-yl)imidazo[1,2- a ]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.著者: Evans, R. / Bolduc, P.N. / Pfaffenbach, M. / Gao, F. / May-Dracka, T. / Fang, T. / Hopkins, B.T. / Chodaparambil, J.V. / Henry, K.L. / Li, P. / Metrick, C. / Nelson, A. / Trapa, P. / Thomas, ... 著者 : Evans, R. / Bolduc, P.N. / Pfaffenbach, M. / Gao, F. / May-Dracka, T. / Fang, T. / Hopkins, B.T. / Chodaparambil, J.V. / Henry, K.L. / Li, P. / Metrick, C. / Nelson, A. / Trapa, P. / Thomas, A. / Burkly, L. / Peterson, E.A. 履歴 登録 2023年9月26日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2024年6月26日 Provider : repository / タイプ : Initial release