登録情報 データベース : PDB / ID : 8uc4 構造の表示 ダウンロードとリンクタイトル Apo X-ray crystal structure of Cyclophilin D with a surface entropy reduction mutation (K175I) 要素Peptidyl-prolyl cis-trans isomerase F, mitochondrial 詳細 キーワード ISOMERASE / Cyclophilin D / mitochondria機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of proton-transporting ATPase activity, rotational mechanism / negative regulation of oxidative phosphorylation uncoupler activity / mitochondrial outer membrane permeabilization involved in programmed cell death / regulation of mitochondrial membrane permeability involved in programmed necrotic cell death / skeletal muscle fiber differentiation / mitochondrial permeability transition pore complex / mitochondrial depolarization / cellular response to arsenic-containing substance / negative regulation of ATP-dependent activity / negative regulation of oxidative phosphorylation ... regulation of proton-transporting ATPase activity, rotational mechanism / negative regulation of oxidative phosphorylation uncoupler activity / mitochondrial outer membrane permeabilization involved in programmed cell death / regulation of mitochondrial membrane permeability involved in programmed necrotic cell death / skeletal muscle fiber differentiation / mitochondrial permeability transition pore complex / mitochondrial depolarization / cellular response to arsenic-containing substance / negative regulation of ATP-dependent activity / negative regulation of oxidative phosphorylation / regulation of mitochondrial membrane permeability / cyclosporin A binding / negative regulation of release of cytochrome c from mitochondria / necroptotic process / apoptotic mitochondrial changes / protein peptidyl-prolyl isomerization / negative regulation of intrinsic apoptotic signaling pathway / cellular response to calcium ion / peptide binding / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / response to ischemia / cellular response to hydrogen peroxide / protein folding / mitochondrial inner membrane / mitochondrial matrix / negative regulation of apoptotic process / mitochondrion / membrane / cytoplasm 類似検索 - 分子機能 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site / Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain profile. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain / Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD / Cyclophilin-like domain superfamily 類似検索 - ドメイン・相同性 DI(HYDROXYETHYL)ETHER / Peptidyl-prolyl cis-trans isomerase F, mitochondrial 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.87 Å 詳細データ登録者 Kreitler, D.F. / Rangwala, A.M. / Seeliger, M.A. 資金援助 米国, 3件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) P30GM133893 米国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R35GM119437 米国 National Institutes of Health/National Cancer Institute (NIH/NCI) F30CA260771 米国
引用ジャーナル : To Be Published タイトル : Apo X-ray crystal structure of Cyclophilin D with a surface entropy reduction mutation (K175I)著者 : Kreitler, D.F. / Seeliger, M.A. / Rangwala, A.M. 履歴 登録 2023年9月25日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2024年8月7日 Provider : repository / タイプ : Initial release