登録情報 | データベース: PDB / ID: 8u2y |
---|
タイトル | Solution structure of the PHD6 finger of MLL4 bound to TET3 |
---|
要素 | - Histone-lysine N-methyltransferase 2D
- Methylcytosine dioxygenase TET3
|
---|
キーワード | GENE REGULATION / KMT2D / TET3 / chromatin / epigenetics |
---|
機能・相同性 | 機能・相同性情報
epigenetic programing of male pronucleus / : / beta-catenin-TCF complex assembly / : / 5-methylcytosine catabolic process / 5-methylcytosine dioxygenase activity / oocyte growth / TET1,2,3 and TDG demethylate DNA / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity ...epigenetic programing of male pronucleus / : / beta-catenin-TCF complex assembly / : / 5-methylcytosine catabolic process / 5-methylcytosine dioxygenase activity / oocyte growth / TET1,2,3 and TDG demethylate DNA / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / : / histone H3K4 trimethyltransferase activity / oxidative demethylation / protein O-linked glycosylation / MLL3/4 complex / methyl-CpG binding / male pronucleus / female pronucleus / histone H3K4 methyltransferase activity / positive regulation of intracellular estrogen receptor signaling pathway / oogenesis / Formation of WDR5-containing histone-modifying complexes / heterochromatin formation / Deactivation of the beta-catenin transactivating complex / Formation of the beta-catenin:TCF transactivating complex / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / PKMTs methylate histone lysines / Activation of anterior HOX genes in hindbrain development during early embryogenesis / response to estrogen / chromosome / histone binding / methylation / transcription coactivator activity / transcription cis-regulatory region binding / positive regulation of cell population proliferation / regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / nucleus / metal ion binding / cytoplasm類似検索 - 分子機能 Histone-lysine N-methyltransferase 2D / KMT2D, ePHD1 domain / KMT2D, ePHD2 domain / : / : / Methylcytosine dioxygenase TET1/2/3 / Oxygenase domain of the 2OGFeDO superfamily / 2OGFeDO, oxygenase domain / Oxygenase domain of the 2OGFeDO superfamily / FY-rich, N-terminal ...Histone-lysine N-methyltransferase 2D / KMT2D, ePHD1 domain / KMT2D, ePHD2 domain / : / : / Methylcytosine dioxygenase TET1/2/3 / Oxygenase domain of the 2OGFeDO superfamily / 2OGFeDO, oxygenase domain / Oxygenase domain of the 2OGFeDO superfamily / FY-rich, N-terminal / F/Y-rich N-terminus / PHD-like zinc-binding domain / FYR domain FYRN motif profile. / "FY-rich" domain, N-terminal region / FY-rich, C-terminal / F/Y rich C-terminus / FYR domain FYRC motif profile. / "FY-rich" domain, C-terminal region / CXXC zinc finger domain / Zinc finger, CXXC-type / Zinc finger CXXC-type profile. / Cysteine-rich motif following a subset of SET domains / Post-SET domain / Post-SET domain profile. / high mobility group / High mobility group box domain / High mobility group box domain superfamily / PHD-zinc-finger like domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. / SET domain profile. / SET domain / PHD-finger / Ring finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, FYVE/PHD-type / Zinc finger, RING/FYVE/PHD-type類似検索 - ドメイン・相同性 Histone-lysine N-methyltransferase 2D / Methylcytosine dioxygenase TET3類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | 溶液NMR / simulated annealing |
---|
データ登録者 | Mohid, S.A. / Zandian, M. / Zhang, Y. / Kutateladze, T.G. |
---|
資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
---|
National Institutes of Health/National Cancer Institute (NIH/NCI) | | 米国 |
|
---|
引用 | ジャーナル: Structure / 年: 2024 タイトル: MLL4 binds TET3. 著者: Becht, D.C. / Mohid, S.A. / Lee, J.E. / Zandian, M. / Benz, C. / Biswas, S. / Sinha, V.K. / Ivarsson, Y. / Ge, K. / Zhang, Y. / Kutateladze, T.G. |
---|
履歴 | 登録 | 2023年9月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2024年6月19日 | Provider: repository / タイプ: Initial release |
---|
|
---|
Remark 650 | HELIX DETERMINATION METHOD: AUTHOR |
---|
Remark 700 | SHEET DETERMINATION METHOD: AUTHOR |
---|