Entry Database : PDB / ID : 8tbx Structure visualization Downloads & linksTitle Crystal structure of human DDX1 helicase in complex with ADP ComponentsATP-dependent RNA helicase DDX1 Details Keywords RNA BINDING PROTEIN / DDX1 / helicase / SGC / RNA helicaseFunction / homology Function and homology informationFunction Domain/homology Component
cleavage body / DNA/RNA helicase activity / tRNA-splicing ligase complex / : / tRNA splicing, via endonucleolytic cleavage and ligation / protein localization to cytoplasmic stress granule / positive regulation of myeloid dendritic cell cytokine production / nuclease activity / poly(A) binding / tRNA processing in the nucleus ... cleavage body / DNA/RNA helicase activity / tRNA-splicing ligase complex / : / tRNA splicing, via endonucleolytic cleavage and ligation / protein localization to cytoplasmic stress granule / positive regulation of myeloid dendritic cell cytokine production / nuclease activity / poly(A) binding / tRNA processing in the nucleus / regulation of translational initiation / exonuclease activity / DNA duplex unwinding / response to exogenous dsRNA / spliceosomal complex assembly / transcription coregulator activity / cytoplasmic stress granule / double-stranded RNA binding / double-strand break repair / positive regulation of canonical NF-kappaB signal transduction / defense response to virus / RNA helicase activity / RNA helicase / ribonucleoprotein complex / innate immune response / chromatin binding / ATP hydrolysis activity / mitochondrion / DNA binding / RNA binding / nucleoplasm / ATP binding / membrane / nucleus / cytoplasm / cytosol Similarity search - Function RNA helicase, DEAD-box type, Q motif / DEAD-box RNA helicase Q motif profile. / SPRY domain / B30.2/SPRY domain / B30.2/SPRY domain profile. / SPRY domain / B30.2/SPRY domain superfamily / Domain in SPla and the RYanodine Receptor. / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain ... RNA helicase, DEAD-box type, Q motif / DEAD-box RNA helicase Q motif profile. / SPRY domain / B30.2/SPRY domain / B30.2/SPRY domain profile. / SPRY domain / B30.2/SPRY domain superfamily / Domain in SPla and the RYanodine Receptor. / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / Concanavalin A-like lectin/glucanase domain superfamily / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.71 Å DetailsAuthors Zeng, H. / Dong, A. / Li, Y. / Yen, H. / Hejazi, Z. / Seitova, A. / Arrowsmith, C.H. / Edwards, A.M. / Halabelian, L. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute on Aging (NIH/NIA) U54 AG065187 United States
CitationJournal : To be published Title : Crystal structure of human DDX1 helicase in complex with ADPAuthors : Zeng, H. / Dong, A. / Li, Y. / Yen, H. / Hejazi, Z. / Seitova, A. / Arrowsmith, C.H. / Edwards, A.M. / Halabelian, L. History Deposition Jun 29, 2023 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 26, 2023 Provider : repository / Type : Initial releaseRevision 1.1 Aug 16, 2023 Group : Author supporting evidence / Data collectionCategory : chem_comp_atom / chem_comp_bond / pdbx_audit_supportItem : _pdbx_audit_support.country / _pdbx_audit_support.funding_organization / _pdbx_audit_support.grant_number
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