登録情報 | データベース: PDB / ID: 8t8s |
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タイトル | Sortilin-PGRN peptide complex |
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要素 | - Paragranulin peptide
- Sortilin
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キーワード | TRANSPORT PROTEIN / Sortilin / Progranulin |
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機能・相同性 | 機能・相同性情報
positive regulation of aspartic-type peptidase activity / positive regulation of inflammatory response to wounding / negative regulation of neutrophil activation / positive regulation of protein folding / neurotensin receptor activity, non-G protein-coupled / negative regulation of lipoprotein lipase activity / microglial cell activation involved in immune response / Golgi to lysosome transport / positive regulation of lysosome organization / myotube differentiation ...positive regulation of aspartic-type peptidase activity / positive regulation of inflammatory response to wounding / negative regulation of neutrophil activation / positive regulation of protein folding / neurotensin receptor activity, non-G protein-coupled / negative regulation of lipoprotein lipase activity / microglial cell activation involved in immune response / Golgi to lysosome transport / positive regulation of lysosome organization / myotube differentiation / cerebellar climbing fiber to Purkinje cell synapse / positive regulation of defense response to bacterium / negative regulation of microglial cell activation / plasma membrane to endosome transport / maintenance of synapse structure / retromer complex binding / Golgi to endosome transport / nerve growth factor receptor activity / vesicle organization / endosome transport via multivesicular body sorting pathway / lysosomal lumen acidification / nerve growth factor binding / protein targeting to lysosome / trans-Golgi network transport vesicle / astrocyte activation involved in immune response / clathrin-coated vesicle / lysosomal transport / Golgi cisterna membrane / Golgi Associated Vesicle Biogenesis / lysosome organization / negative regulation of fat cell differentiation / endosome to lysosome transport / positive regulation of axon regeneration / glucose import / neurotrophin TRK receptor signaling pathway / negative regulation of respiratory burst involved in inflammatory response / extrinsic apoptotic signaling pathway via death domain receptors / neuropeptide signaling pathway / clathrin-coated pit / positive regulation of endothelial cell migration / ossification / positive regulation of epithelial cell proliferation / cytokine activity / growth factor activity / response to insulin / trans-Golgi network / endocytosis / positive regulation of angiogenesis / positive regulation of neuron apoptotic process / azurophil granule lumen / late endosome / protein-folding chaperone binding / regulation of inflammatory response / cytoplasmic vesicle / regulation of gene expression / nuclear membrane / negative regulation of neuron apoptotic process / early endosome / lysosome / protein stabilization / endosome membrane / endosome / positive regulation of cell migration / G protein-coupled receptor signaling pathway / lysosomal membrane / Neutrophil degranulation / endoplasmic reticulum membrane / perinuclear region of cytoplasm / Golgi apparatus / enzyme binding / cell surface / signal transduction / endoplasmic reticulum / RNA binding / extracellular space / extracellular exosome / extracellular region / membrane / plasma membrane / cytosol類似検索 - 分子機能 Granulins signature. / Granulin family / Granulin / Granulin superfamily / Granulin / Granulin / VPS10 / Sortilin, C-terminal / Sortilin, N-terminal / Sortilin, neurotensin receptor 3, C-terminal ...Granulins signature. / Granulin family / Granulin / Granulin superfamily / Granulin / Granulin / VPS10 / Sortilin, C-terminal / Sortilin, N-terminal / Sortilin, neurotensin receptor 3, C-terminal / Sortilin, neurotensin receptor 3, / VPS10 / WD40/YVTN repeat-like-containing domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.99 Å |
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データ登録者 | Srivastava, D.B. / Srivastava, A. / Cherf, G.M. / Low, L.Y. / Kannan, G. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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Other private | | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Structural studies of Sortilin-PGRN peptide complex 著者: Srivastava, D.B. / Cherf, G.M. / Low, L.Y. / Kannan, G. |
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履歴 | 登録 | 2023年6月23日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2024年6月26日 | Provider: repository / タイプ: Initial release |
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