登録情報 データベース : PDB / ID : 8szp 構造の表示 ダウンロードとリンクタイトル Human DHX9 bound to ADP 要素ATP-dependent RNA helicase A 詳細 キーワード HYDROLASE / DExH-box / RHA機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
catalytic activity, acting on a nucleic acid / 3'-5' DNA/RNA helicase activity / CRD-mediated mRNA stability complex / regulatory region RNA binding / DNA-templated viral transcription / positive regulation of RNA export from nucleus / regulation of cytoplasmic translation / positive regulation of viral transcription / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / triplex DNA binding ... catalytic activity, acting on a nucleic acid / 3'-5' DNA/RNA helicase activity / CRD-mediated mRNA stability complex / regulatory region RNA binding / DNA-templated viral transcription / positive regulation of RNA export from nucleus / regulation of cytoplasmic translation / positive regulation of viral transcription / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / triplex DNA binding / RISC complex binding / CRD-mediated mRNA stabilization / nucleoside triphosphate diphosphatase activity / importin-alpha family protein binding / protein localization to cytoplasmic stress granule / perichromatin fibrils / positive regulation of interleukin-18 production / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / nuclear stress granule / 3'-5' RNA helicase activity / alternative mRNA splicing, via spliceosome / miRNA-mediated post-transcriptional gene silencing / RISC-loading complex / regulation of mRNA processing / regulation of defense response to virus by host / RISC complex assembly / positive regulation of response to cytokine stimulus / RIP-mediated NFkB activation via ZBP1 / siRNA binding / positive regulation of cytoplasmic translation / RISC complex / sequence-specific mRNA binding / positive regulation of innate immune response / RNA polymerase binding / 3'-5' DNA helicase activity / cellular response to exogenous dsRNA / pyroptotic inflammatory response / RNA polymerase II complex binding / positive regulation of interferon-alpha production / DNA replication origin binding / mRNA transport / DNA helicase activity / mRNA Splicing - Major Pathway / positive regulation of interferon-beta production / ribonucleoside triphosphate phosphatase activity / positive regulation of DNA repair / positive regulation of DNA replication / transcription coregulator activity / promoter-specific chromatin binding / DNA-templated transcription termination / positive regulation of NF-kappaB transcription factor activity / PKR-mediated signaling / chromatin DNA binding / positive regulation of interleukin-6 production / cytoplasmic ribonucleoprotein granule / RNA stem-loop binding / positive regulation of fibroblast proliferation / positive regulation of inflammatory response / osteoblast differentiation / positive regulation of tumor necrosis factor production / rhythmic process / actin cytoskeleton / single-stranded DNA binding / double-stranded RNA binding / ribosome binding / chromatin organization / protein-containing complex assembly / double-stranded DNA binding / RNA polymerase II-specific DNA-binding transcription factor binding / single-stranded 3'-5' DNA helicase activity / transcription coactivator activity / DNA replication / single-stranded RNA binding / RNA helicase activity / nuclear body / RNA helicase / RNA polymerase II cis-regulatory region sequence-specific DNA binding / ribonucleoprotein complex / innate immune response / mRNA binding / centrosome / regulation of transcription by RNA polymerase II / nucleolus / positive regulation of transcription by RNA polymerase II / protein-containing complex / ATP hydrolysis activity / DNA binding / RNA binding / nucleoplasm / ATP binding / metal ion binding / nucleus / membrane / cytosol / cytoplasm 類似検索 - 分子機能 DHX9, first double-stranded RNA binding domain / DHX9, second double-stranded RNA binding domain / DHX9, DEXH-box helicase domain / : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase associated domain (HA2), winged-helix / Helicase-associated domain / Helicase associated domain (HA2) Add an annotation ... DHX9, first double-stranded RNA binding domain / DHX9, second double-stranded RNA binding domain / DHX9, DEXH-box helicase domain / : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase associated domain (HA2), winged-helix / Helicase-associated domain / Helicase associated domain (HA2) Add an annotation / Double-stranded RNA binding motif / Double-stranded RNA binding motif / DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site / DEAH-box subfamily ATP-dependent helicases signature. / Double stranded RNA-binding domain (dsRBD) profile. / Double-stranded RNA-binding domain / DEAD/DEAH box helicase domain / DEAD/DEAH box helicase / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleoside triphosphate hydrolase 類似検索 - ドメイン・相同性 ADENOSINE-5'-DIPHOSPHATE / ATP-dependent RNA helicase A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.62 Å 詳細データ登録者 Lee, Y.-T. / Sickmier, E.A. / Grigoriu, S. / Boriack-Sjodin, P.A. 資金援助 1件 詳細 詳細を隠す 引用ジャーナル : Acta Crystallogr D Struct Biol / 年 : 2023タイトル : Crystal structures of the DExH-box RNA helicase DHX9.著者 : Lee, Y.T. / Sickmier, E.A. / Grigoriu, S. / Castro, J. / Boriack-Sjodin, P.A. 履歴 登録 2023年5月30日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2023年8月2日 Provider : repository / タイプ : Initial release改定 1.1 2023年11月1日 Group : Data collection / Database referencesカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / citation_author Item : _citation.journal_abbrev / _citation.journal_id_CSD ... _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name 改定 1.2 2023年11月8日 Group : Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last
すべて表示 表示を減らす