登録情報 データベース : PDB / ID : 8svy 構造の表示 ダウンロードとリンクタイトル MBP-Mcl1 in complex with ligand 10 要素Maltose/maltodextrin-binding periplasmic protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera 詳細 キーワード SIGNALING PROTEIN / Myeloid cell leukemia 1 / Mcl-1 / B-cell lymphoma 2 / Bcl-2 / BH3 mimetic / Protein-protein interaction / Modulator / Apoptosis / Cancer / Leukemia / Myeloma / Lymphoma機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cellular homeostasis / cell fate determination / channel activity / mitochondrial fusion / Bcl-2 family protein complex / BH3 domain binding / carbohydrate transmembrane transporter activity / negative regulation of anoikis / maltose binding ... positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cellular homeostasis / cell fate determination / channel activity / mitochondrial fusion / Bcl-2 family protein complex / BH3 domain binding / carbohydrate transmembrane transporter activity / negative regulation of anoikis / maltose binding / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / maltose transport / maltodextrin transmembrane transport / protein transmembrane transporter activity / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of autophagy / release of cytochrome c from mitochondria / response to cytokine / intrinsic apoptotic signaling pathway in response to DNA damage / Signaling by ALK fusions and activated point mutants / outer membrane-bounded periplasmic space / regulation of apoptotic process / Interleukin-4 and Interleukin-13 signaling / mitochondrial outer membrane / positive regulation of apoptotic process / protein heterodimerization activity / DNA damage response / negative regulation of apoptotic process / protein homodimerization activity / mitochondrion / nucleoplasm / membrane / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Apoptosis regulator, Mcl-1 / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 ... Apoptosis regulator, Mcl-1 / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / Apoptosis regulator proteins, Bcl-2 family / BCL2-like apoptosis inhibitors family profile. / Bcl-2-like superfamily / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein 類似検索 - ドメイン・相同性 alpha-maltose / Chem-WUC / Maltose/maltodextrin-binding periplasmic protein / Induced myeloid leukemia cell differentiation protein Mcl-1 類似検索 - 構成要素生物種 Escherichia coli (大腸菌)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.47 Å 詳細データ登録者 Miller, B.R. / Shaffer, P. 資金援助 1件 詳細 詳細を隠す 引用ジャーナル : Acs Med.Chem.Lett. / 年 : 2023タイトル : Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1.著者: Demin, S. / Peschiulli, A. / Velter, A.I. / Vos, A. / De Boeck, B. / Miller, B. / Rombouts, F.J.R. / Reuillon, T. / Lento, W. / Blanco, M.D. / Jouffroy, M. / Steyvers, H. / Bekkers, M. / ... 著者 : Demin, S. / Peschiulli, A. / Velter, A.I. / Vos, A. / De Boeck, B. / Miller, B. / Rombouts, F.J.R. / Reuillon, T. / Lento, W. / Blanco, M.D. / Jouffroy, M. / Steyvers, H. / Bekkers, M. / Altrocchi, C. / Pietrak, B. / Koo, S.J. / Szewczuk, L. / Attar, R. / Philippar, U. 履歴 登録 2023年5月17日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2023年8月9日 Provider : repository / タイプ : Initial release改定 1.1 2024年5月22日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond
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