登録情報 | データベース: PDB / ID: 8s4y |
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タイトル | Crystal structure of an APP-talin (F2F3) chimera |
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要素 | |
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キーワード | CELL ADHESION / Amyloid precursor protein / talin / FERM domains / chimera / Alzheimer's disease |
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機能・相同性 | 機能・相同性情報
Formyl peptide receptors bind formyl peptides and many other ligands / Advanced glycosylation endproduct receptor signaling / ECM proteoglycans / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / TRAF6 mediated NF-kB activation / Lysosome Vesicle Biogenesis / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Post-translational protein phosphorylation / TAK1-dependent IKK and NF-kappa-B activation / G alpha (q) signalling events ...Formyl peptide receptors bind formyl peptides and many other ligands / Advanced glycosylation endproduct receptor signaling / ECM proteoglycans / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / TRAF6 mediated NF-kB activation / Lysosome Vesicle Biogenesis / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Post-translational protein phosphorylation / TAK1-dependent IKK and NF-kappa-B activation / G alpha (q) signalling events / G alpha (i) signalling events / Platelet degranulation / central nervous system neuron differentiation / Mitochondrial protein degradation / negative regulation of presynapse assembly / collateral sprouting in absence of injury / cytosolic mRNA polyadenylation / synaptic assembly at neuromuscular junction / regulation of synapse structure or activity / axo-dendritic transport / axon midline choice point recognition / smooth endoplasmic reticulum calcium ion homeostasis / mating behavior / ciliary rootlet / Golgi-associated vesicle / neuron remodeling / suckling behavior / COPII-coated ER to Golgi transport vesicle / intracellular vesicle / dendrite development / presynaptic active zone / signaling receptor activator activity / neuromuscular process controlling balance / transition metal ion binding / regulation of multicellular organism growth / intracellular copper ion homeostasis / negative regulation of neuron differentiation / spindle midzone / forebrain development / smooth endoplasmic reticulum / ruffle / clathrin-coated pit / Notch signaling pathway / positive regulation of G2/M transition of mitotic cell cycle / extracellular matrix organization / ionotropic glutamate receptor signaling pathway / axonogenesis / cholesterol metabolic process / positive regulation of mitotic cell cycle / adult locomotory behavior / locomotory behavior / serine-type endopeptidase inhibitor activity / cell-cell adhesion / visual learning / recycling endosome / neuromuscular junction / structural constituent of cytoskeleton / ruffle membrane / cognition / long-term synaptic potentiation / memory / neuron cellular homeostasis / endocytosis / neuron projection development / neuron differentiation / G2/M transition of mitotic cell cycle / actin filament binding / integrin binding / apical part of cell / synaptic vesicle / cell-cell junction / mitotic cell cycle / heparin binding / regulation of gene expression / regulation of translation / growth cone / cytoplasmic vesicle / perikaryon / neuron apoptotic process / response to oxidative stress / gene expression / cytoskeleton / early endosome / neuron projection / receptor complex / cell adhesion / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein domain specific binding / axon / focal adhesion / protein kinase binding / perinuclear region of cytoplasm / cell surface / endoplasmic reticulum / Golgi apparatus / positive regulation of transcription by RNA polymerase II / extracellular region / identical protein binding / nucleus / membrane類似検索 - 分子機能 Talin VBS2 domain / Vinculin-binding site-containing domain / Talin, central / Talin, central domain superfamily / Talin-1/2, rod-segment / : / : / Vinculin Binding Site / Talin, middle domain / Talin, R4 domain ...Talin VBS2 domain / Vinculin-binding site-containing domain / Talin, central / Talin, central domain superfamily / Talin-1/2, rod-segment / : / : / Vinculin Binding Site / Talin, middle domain / Talin, R4 domain / Talin 1-like, rod segment domain / Talin, N-terminal F0 domain / : / N-terminal or F0 domain of Talin-head FERM / Talin IBS2B domain / I/LWEQ domain / I/LWEQ domain superfamily / I/LWEQ domain / I/LWEQ domain profile. / I/LWEQ domain / Phosphotyrosine-binding domain / IRS-type PTB domain / PTB domain (IRS-1 type) / Alpha-catenin/vinculin-like superfamily / FERM, N-terminal / FERM N-terminal domain / FERM domain signature 1. / FERM conserved site / FERM domain signature 2. / Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Beta-amyloid peptide (beta-APP) / Amyloidogenic glycoprotein, amyloid-beta peptide / Beta-amyloid precursor protein C-terminal / Amyloidogenic glycoprotein, intracellular domain, conserved site / Beta-amyloid precursor protein C-terminus / Amyloid precursor protein (APP) intracellular domain signature. / Amyloidogenic glycoprotein, extracellular / Amyloidogenic glycoprotein, heparin-binding / Amyloidogenic glycoprotein, E2 domain / E2 domain superfamily / Amyloidogenic glycoprotein, heparin-binding domain superfamily / Amyloid A4 N-terminal heparin-binding / E2 domain of amyloid precursor protein / Amyloid precursor protein (APP) E1 domain profile. / Amyloid precursor protein (APP) E2 domain profile. / amyloid A4 / Amyloidogenic glycoprotein / FERM central domain / FERM/acyl-CoA-binding protein superfamily / Proteinase inhibitor I2, Kunitz, conserved site / Pancreatic trypsin inhibitor (Kunitz) family signature. / BPTI/Kunitz family of serine protease inhibitors. / Pancreatic trypsin inhibitor Kunitz domain / Kunitz/Bovine pancreatic trypsin inhibitor domain / Pancreatic trypsin inhibitor (Kunitz) family profile. / Pancreatic trypsin inhibitor Kunitz domain superfamily / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / PH-like domain superfamily / Ubiquitin-like domain superfamily類似検索 - ドメイン・相同性 |
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生物種 |  Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.7 Å |
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データ登録者 | Ball, N.J. / Ellis, C. / Goult, B.T. |
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資金援助 | 英国, 1件 組織 | 認可番号 | 国 |
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Cancer Research UK | | 英国 |
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引用 | ジャーナル: Open Biology / 年: 2024 タイトル: The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer's disease. 著者: Ellis, C. / Ward, N.L. / Rice, M. / Ball, N.J. / Walle, P. / Najdek, C. / Kilinc, D. / Lambert, J.C. / Chapuis, J. / Goult, B.T. |
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履歴 | 登録 | 2024年2月22日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2024年10月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2025年4月30日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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