- PDB-8rdk: Crystal structure of human Haspin (GSG2) kinase bound to MD420 -
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基本情報
登録情報
データベース: PDB / ID: 8rdk
タイトル
Crystal structure of human Haspin (GSG2) kinase bound to MD420
要素
Serine/threonine-protein kinase haspin
キーワード
TRANSFERASE / Haspin / Kinase / Inhibitor
機能・相同性
機能・相同性情報
histone H3T3 kinase activity / protein localization to chromosome, centromeric region / mitotic sister chromatid cohesion / mitotic spindle assembly checkpoint signaling / spindle / chromosome / mitotic cell cycle / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction ...histone H3T3 kinase activity / protein localization to chromosome, centromeric region / mitotic sister chromatid cohesion / mitotic spindle assembly checkpoint signaling / spindle / chromosome / mitotic cell cycle / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / centrosome / nucleoplasm / ATP binding / nucleus / cytoplasm 類似検索 - 分子機能
Serine/threonine-protein kinase haspin, C-terminal / Domain of unknown function / Haspin like kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性
構造決定の手法: 分子置換 / 解像度: 2→52.01 Å / Cor.coef. Fo:Fc: 0.959 / Cor.coef. Fo:Fc free: 0.943 / SU B: 8.726 / SU ML: 0.115 / 交差検証法: THROUGHOUT / ESU R: 0.15 / ESU R Free: 0.142 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.23294
1599
4.9 %
RANDOM
Rwork
0.19695
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obs
0.19868
31054
99.97 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK