登録情報 | データベース: PDB / ID: 8rd1 |
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タイトル | HUWE1 WWE domain in complex with compound 4 |
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要素 | E3 ubiquitin-protein ligase HUWE1 |
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キーワード | LIGASE / WWE domain |
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機能・相同性 | 機能・相同性情報
histone ubiquitin ligase activity / negative regulation of mitochondrial fusion / : / HECT-type E3 ubiquitin transferase / positive regulation of protein targeting to mitochondrion / Golgi organization / protein monoubiquitination / positive regulation of protein ubiquitination / circadian regulation of gene expression / base-excision repair ...histone ubiquitin ligase activity / negative regulation of mitochondrial fusion / : / HECT-type E3 ubiquitin transferase / positive regulation of protein targeting to mitochondrion / Golgi organization / protein monoubiquitination / positive regulation of protein ubiquitination / circadian regulation of gene expression / base-excision repair / protein polyubiquitination / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / ubiquitin-dependent protein catabolic process / secretory granule lumen / ficolin-1-rich granule lumen / membrane fusion / cell differentiation / Golgi membrane / Neutrophil degranulation / mitochondrion / DNA binding / RNA binding / extracellular exosome / extracellular region / nucleoplasm / membrane / nucleus / cytosol / cytoplasm類似検索 - 分子機能 HUWE1, UBA domain / E3 ubiquitin ligase, domain of unknown function DUF908 / E3 ubiquitin ligase, domain of unknown function DUF913 / Domain of Unknown Function (DUF908) / Domain of Unknown Function (DUF913) / HUWE1/Rev1, ubiquitin binding region / Ubiquitin binding region / UBA-like domain / WWE domain / WWE domain superfamily ...HUWE1, UBA domain / E3 ubiquitin ligase, domain of unknown function DUF908 / E3 ubiquitin ligase, domain of unknown function DUF913 / Domain of Unknown Function (DUF908) / Domain of Unknown Function (DUF913) / HUWE1/Rev1, ubiquitin binding region / Ubiquitin binding region / UBA-like domain / WWE domain / WWE domain superfamily / WWE domain / WWE domain profile. / : / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / Ubiquitin associated domain / Ubiquitin-associated domain / Ubiquitin-associated domain (UBA) profile. / UBA-like superfamily / Armadillo-type fold類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.896 Å |
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データ登録者 | Muenzker, L. / Zak, K.M. / Boettcher, J. |
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資金援助 | European Union, 1件 組織 | 認可番号 | 国 |
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European Union (EU) | 875510 | European Union |
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引用 | ジャーナル: Commun Biol / 年: 2024 タイトル: A ligand discovery toolbox for the WWE domain family of human E3 ligases. 著者: Munzker, L. / Kimani, S.W. / Fowkes, M.M. / Dong, A. / Zheng, H. / Li, Y. / Dasovich, M. / Zak, K.M. / Leung, A.K.L. / Elkins, J.M. / Kessler, D. / Arrowsmith, C.H. / Halabelian, L. / Bottcher, J. |
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履歴 | 登録 | 2023年12月7日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2024年7月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年8月7日 | Group: Database references / カテゴリ: citation Item: _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title |
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