Entry | Database: PDB / ID: 8r03 |
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Title | Staphylococcus aureus ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.0 A resolution |
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Components | ATP-dependent Clp protease proteolytic subunit |
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Keywords | HYDROLASE / anti-virulence / caseinolytic protease / inhibitor / natural product / mode of action |
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Function / homology | Function and homology information
endopeptidase Clp / endopeptidase Clp complex / ATP-dependent peptidase activity / protein quality control for misfolded or incompletely synthesized proteins / ATPase binding / serine-type endopeptidase activity / cytoplasmSimilarity search - Function ClpP, Ser active site / Endopeptidase Clp serine active site. / ClpP, histidine active site / Endopeptidase Clp histidine active site. / ATP-dependent Clp protease proteolytic subunit / Clp protease proteolytic subunit /Translocation-enhancing protein TepA / Clp protease / ClpP/crotonase-like domain superfamilySimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Staphylococcus aureus (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2 Å |
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Authors | Illigmann, A. / Vielberg, M.-T. / Lakemeyer, M. / Wolf, F. / Staudt, N. / Dema, T. / Stange, P. / Liebhart, E. / Kuttenlochner, W. / Kulik, A. ...Illigmann, A. / Vielberg, M.-T. / Lakemeyer, M. / Wolf, F. / Staudt, N. / Dema, T. / Stange, P. / Liebhart, E. / Kuttenlochner, W. / Kulik, A. / Malik, I. / Grond, S. / Sieber, S.A. / Groll, M. / Kaysser, L. / Broetz-Oesterhelt, H. |
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Funding support | Germany, 1items Organization | Grant number | Country |
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German Research Foundation (DFG) | GR 1861/10-3 | Germany |
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Citation | Journal: Angew.Chem.Int.Ed.Engl. / Year: 2024 Title: Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Authors: Illigmann, A. / Vielberg, M.T. / Lakemeyer, M. / Wolf, F. / Dema, T. / Stange, P. / Kuttenlochner, W. / Liebhart, E. / Kulik, A. / Staudt, N.D. / Malik, I. / Grond, S. / Sieber, S.A. / ...Authors: Illigmann, A. / Vielberg, M.T. / Lakemeyer, M. / Wolf, F. / Dema, T. / Stange, P. / Kuttenlochner, W. / Liebhart, E. / Kulik, A. / Staudt, N.D. / Malik, I. / Grond, S. / Sieber, S.A. / Kaysser, L. / Groll, M. / Brotz-Oesterhelt, H. |
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History | Deposition | Oct 30, 2023 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Dec 20, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 27, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.page_first / _citation.page_last ..._citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID / _citation_author.name |
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Revision 1.2 | Jan 17, 2024 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _citation_author.identifier_ORCID |
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Revision 1.3 | Jan 24, 2024 | Group: Database references / Category: citation / citation_author Item: _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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