登録情報 データベース : PDB / ID : 8qal 構造の表示 ダウンロードとリンクタイトル Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 83 要素Bromodomain-containing protein 4 詳細 キーワード TRANSCRIPTION / four helical bundle機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ... RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus 類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / : / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / : / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.3 Å 詳細データ登録者 Dalle Vedove, A. / Cazzanelli, G. / Lolli, G. 資金援助 イタリア, 1件 詳細 詳細を隠す組織 認可番号 国 Italian Association for Cancer Research MFAG 2017 - ID. 19882 イタリア
引用ジャーナル : To be published タイトル : Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines著者 : Cazzanelli, G. / Dalle Vedove, A. / Caflisch, A. / Lolli, G. 履歴 登録 2023年8月23日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2024年9月11日 Provider : repository / タイプ : Initial release