+Open data
-Basic information
Entry | Database: PDB / ID: 8pnr | ||||||
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Title | Structure of human KCTD15 BTB domain mutant G88D crystal form 1 | ||||||
Components | BTB/POZ domain-containing protein KCTD15 | ||||||
Keywords | GENE REGULATION / Oligomerisation / BTB domain | ||||||
Function / homology | Function and homology information Negative regulation of activity of TFAP2 (AP-2) family transcription factors / protein homooligomerization / identical protein binding / nucleus Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.25 Å | ||||||
Authors | Cruz Walma, D.A. / Cros, J. / Bradshaw, W. / Richardson, W. / Chen, Z. / Chalk, R. / Wilkie, A. / Bullock, A.N. | ||||||
Funding support | United States, 1items
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Citation | Journal: J Med Genet / Year: 2024 Title: BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome. Authors: Miller, K.A. / Cruz Walma, D.A. / Pinkas, D.M. / Tooze, R.S. / Bufton, J.C. / Richardson, W. / Manning, C.E. / Hunt, A.E. / Cros, J. / Hartill, V. / Parker, M.J. / McGowan, S.J. / Twigg, S.R. ...Authors: Miller, K.A. / Cruz Walma, D.A. / Pinkas, D.M. / Tooze, R.S. / Bufton, J.C. / Richardson, W. / Manning, C.E. / Hunt, A.E. / Cros, J. / Hartill, V. / Parker, M.J. / McGowan, S.J. / Twigg, S.R.F. / Chalk, R. / Staunton, D. / Johnson, D. / Wilkie, A.O.M. / Bullock, A.N. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 8pnr.cif.gz | 596.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb8pnr.ent.gz | 412.9 KB | Display | PDB format |
PDBx/mmJSON format | 8pnr.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 8pnr_validation.pdf.gz | 522.7 KB | Display | wwPDB validaton report |
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Full document | 8pnr_full_validation.pdf.gz | 537.9 KB | Display | |
Data in XML | 8pnr_validation.xml.gz | 40.4 KB | Display | |
Data in CIF | 8pnr_validation.cif.gz | 58.4 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/pn/8pnr ftp://data.pdbj.org/pub/pdb/validation_reports/pn/8pnr | HTTPS FTP |
-Related structure data
Related structure data | 8pnmC C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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