登録情報 | データベース: PDB / ID: 8p8c |
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タイトル | HUMAN CD38 ECTODOMAIN BOUND TO COMPOUND 9-ADPR ADDUCT |
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要素 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
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キーワード | HYDROLASE / CD38 / NAD+ / NUCLEOPHILIC / COVALENT INHIBITOR |
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機能・相同性 | 機能・相同性情報
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase / phosphorus-oxygen lyase activity / artery smooth muscle contraction / Nicotinate metabolism / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase / NAD+ nucleosidase activity / NAD metabolic process / NAD+ nucleotidase, cyclic ADP-ribose generating / negative regulation of bone resorption / long-term synaptic depression ...2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase / phosphorus-oxygen lyase activity / artery smooth muscle contraction / Nicotinate metabolism / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase / NAD+ nucleosidase activity / NAD metabolic process / NAD+ nucleotidase, cyclic ADP-ribose generating / negative regulation of bone resorption / long-term synaptic depression / response to hydroperoxide / 加水分解酵素; 糖加水分解酵素; N-グリコシル化合物加水分解酵素 / B cell proliferation / response to retinoic acid / positive regulation of B cell proliferation / positive regulation of vasoconstriction / response to interleukin-1 / response to progesterone / female pregnancy / apoptotic signaling pathway / B cell receptor signaling pathway / positive regulation of insulin secretion / negative regulation of neuron projection development / response to estradiol / positive regulation of cytosolic calcium ion concentration / transferase activity / positive regulation of cell growth / basolateral plasma membrane / nuclear membrane / response to hypoxia / response to xenobiotic stimulus / negative regulation of DNA-templated transcription / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / cell surface / signal transduction / extracellular exosome / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Chem-X5T / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.653 Å |
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データ登録者 | Rangel, V. / Zebisch, M. / Doyle, K.J. / Burli, R.W. |
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資金援助 | 1件 |
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引用 | ジャーナル: Helv.Chim.Acta / 年: 2023 タイトル: A Covalent Binding Mode of a Pyrazole-Based CD38 Inhibitor 著者: Doyle, K. / Roberts, M. / Harvey, J. / Hewer, R. / Zebisch, M. / Rangel, V. / Gu, M. / Wu, Y. / Yang, L. / Carlton, M. / Dawson, L. / Burli, R. |
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履歴 | 登録 | 2023年5月31日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年7月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年2月7日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.title / _citation.year |
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