Entry Database : PDB / ID : 8p6q Structure visualization Downloads & linksTitle Racemic structure of TNFR1 cysteine-rich domain ComponentsD-TNFR-1 CRD2 Tumor necrosis factor-binding protein 1 DetailsKeywords CYTOKINE / Racemic / Chemical Synthesis / Cysteine-rich / Cytokine Receptor / Receptor MimicFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of amide metabolic process / tumor necrosis factor receptor superfamily complex / pulmonary valve development / aortic valve development / tumor necrosis factor receptor activity / positive regulation of lipid metabolic process / negative regulation of extracellular matrix constituent secretion / positive regulation of apoptotic process involved in morphogenesis / regulation of membrane lipid metabolic process / TNFs bind their physiological receptors ... positive regulation of amide metabolic process / tumor necrosis factor receptor superfamily complex / pulmonary valve development / aortic valve development / tumor necrosis factor receptor activity / positive regulation of lipid metabolic process / negative regulation of extracellular matrix constituent secretion / positive regulation of apoptotic process involved in morphogenesis / regulation of membrane lipid metabolic process / TNFs bind their physiological receptors / negative regulation of cardiac muscle hypertrophy / tumor necrosis factor binding / TNF signaling / regulation of establishment of endothelial barrier / TNFR1-mediated ceramide production / regulation of tumor necrosis factor-mediated signaling pathway / TNFR1-induced proapoptotic signaling / prostaglandin metabolic process / positive regulation of execution phase of apoptosis / Interleukin-10 signaling / extrinsic apoptotic signaling pathway via death domain receptors / positive regulation of tyrosine phosphorylation of STAT protein / tumor necrosis factor-mediated signaling pathway / TNFR1-induced NF-kappa-B signaling pathway / protein localization to plasma membrane / Regulation of TNFR1 signaling / cytokine-mediated signaling pathway / negative regulation of inflammatory response / positive regulation of inflammatory response / cellular response to mechanical stimulus / intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of canonical NF-kappaB signal transduction / transcription by RNA polymerase II / receptor complex / defense response to bacterium / inflammatory response / membrane raft / Golgi membrane / cell surface / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / membrane / plasma membrane Similarity search - Function Tumour necrosis factor receptor 1A / Tumor necrosis factor receptor 1A, N-terminal / Tumor necrosis factor receptor 1A, death domain / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). ... Tumour necrosis factor receptor 1A / Tumor necrosis factor receptor 1A, N-terminal / Tumor necrosis factor receptor 1A, death domain / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.4 Å DetailsAuthors Lander, A.J. / Jin, Y. / Luk, L.Y.P. Funding support United Kingdom, 3items Details Hide detailsOrganization Grant number Country Engineering and Physical Sciences Research Council 2107414 United Kingdom Wellcome Trust 218568/Z/19/Z United Kingdom Biotechnology and Biological Sciences Research Council (BBSRC) BB/T015799/1 United Kingdom
CitationJournal : Acs Bio Med Chem Au / Year : 2024Title : Deciphering the Synthetic and Refolding Strategy of a Cysteine-Rich Domain in the Tumor Necrosis Factor Receptor (TNF-R) for Racemic Crystallography Analysis and d-Peptide Ligand Discovery.Authors : Lander, A.J. / Kong, Y. / Jin, Y. / Wu, C. / Luk, L.Y.P. History Deposition May 28, 2023 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 24, 2024 Provider : repository / Type : Initial releaseRevision 1.1 Mar 6, 2024 Group : Database references / Category : citationItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
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