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Open data
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Basic information
Entry | Database: PDB / ID: 8p42 | ||||||
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Title | Full length structure of TcMIP with bound inhibitor NJS227. | ||||||
![]() | Macrophage infectivity potentiator | ||||||
![]() | STRUCTURAL PROTEIN / Macrophage / potentiator / soluble / protein | ||||||
Function / homology | ![]() peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / chromatin / nucleolus / extracellular region Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Whittaker, J.J. / Guskov, A. / Goretzki, B. / Hellmich, U.A. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Structural dynamics of macrophage infectivity potentiator proteins (MIPs) are differentially modulated by inhibitors and appendage domains Authors: Whittaker, J.J. / Guskov, A. / Goretzki, B. / Hellmich, U.A. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 80.2 KB | Display | ![]() |
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PDB format | ![]() | 60 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 1.4 MB | Display | ![]() |
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Full document | ![]() | 1.4 MB | Display | |
Data in XML | ![]() | 15.1 KB | Display | |
Data in CIF | ![]() | 19.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 8p3cC ![]() 8p3dC C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Links
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Assembly
Deposited unit | ![]()
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2 | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 18186.549 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() #2: Chemical | Mass: 556.624 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C28H30F2N4O4S #3: Chemical | ChemComp-PEG / #4: Water | ChemComp-HOH / | Has ligand of interest | N | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 3.09 Å3/Da / Density % sol: 60.22 % |
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Crystal grow | Temperature: 277 K / Method: vapor diffusion, sitting drop / pH: 7.5 / Details: 5mM TRIS pH 7.5 150mM NaCl PEG2000 12 % |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Sep 10, 2022 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 0.967 Å / Relative weight: 1 |
Reflection | Resolution: 2.64→34.9 Å / Num. obs: 12330 / % possible obs: 94.84 % / Redundancy: 9 % / CC1/2: 0.92 / Net I/σ(I): 13.2 |
Reflection shell | Resolution: 2.64→2.74 Å / Num. unique obs: 1225 / CC1/2: 0.84 |
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Processing
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Refinement | Method to determine structure: ![]()
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Solvent computation | Shrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL | ||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.64→34.88 Å
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Refine LS restraints |
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LS refinement shell |
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