- PDB-8p0d: Human 14-3-3 sigma in complex with human MDM2 peptide -
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Basic information
Entry
Database: PDB / ID: 8p0d
Title
Human 14-3-3 sigma in complex with human MDM2 peptide
Components
14-3-3 protein sigma
E3 ubiquitin-protein ligase Mdm2
Keywords
PROTEIN BINDING / SIGNALING PROTEIN-PEPTIDE complex
Function / homology
Function and homology information
cellular response to vitamin B1 / response to formaldehyde / response to water-immersion restraint stress / traversing start control point of mitotic cell cycle / negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator / response to ether / negative regulation of signal transduction by p53 class mediator / fibroblast activation / atrial septum development / receptor serine/threonine kinase binding ...cellular response to vitamin B1 / response to formaldehyde / response to water-immersion restraint stress / traversing start control point of mitotic cell cycle / negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator / response to ether / negative regulation of signal transduction by p53 class mediator / fibroblast activation / atrial septum development / receptor serine/threonine kinase binding / Trafficking of AMPA receptors / positive regulation of vascular associated smooth muscle cell migration / peroxisome proliferator activated receptor binding / SUMO transferase activity / negative regulation of protein processing / response to iron ion / response to steroid hormone / NEDD8 ligase activity / AKT phosphorylates targets in the cytosol / atrioventricular valve morphogenesis / cellular response to peptide hormone stimulus / ventricular septum development / endocardial cushion morphogenesis / positive regulation of muscle cell differentiation / SUMOylation of ubiquitinylation proteins / regulation of epidermal cell division / protein kinase C inhibitor activity / cellular response to alkaloid / positive regulation of epidermal cell differentiation / blood vessel development / regulation of protein catabolic process / keratinocyte development / keratinization / cardiac septum morphogenesis / Constitutive Signaling by AKT1 E17K in Cancer / ligase activity / negative regulation of DNA damage response, signal transduction by p53 class mediator / response to magnesium ion / SUMOylation of transcription factors / protein sumoylation / Regulation of localization of FOXO transcription factors / protein localization to nucleus / keratinocyte proliferation / phosphoserine residue binding / cellular response to UV-C / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation / blood vessel remodeling / establishment of skin barrier / cellular response to estrogen stimulus / protein autoubiquitination / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / cellular response to actinomycin D / ribonucleoprotein complex binding / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / negative regulation of stem cell proliferation / RHO GTPases activate PKNs / positive regulation of vascular associated smooth muscle cell proliferation / protein kinase A signaling / protein sequestering activity / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / NPAS4 regulates expression of target genes / negative regulation of innate immune response / transcription repressor complex / protein export from nucleus / regulation of heart rate / positive regulation of mitotic cell cycle / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / positive regulation of protein export from nucleus / release of cytochrome c from mitochondria / response to cocaine / proteolysis involved in protein catabolic process / stem cell proliferation / ubiquitin binding / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / Stabilization of p53 / Regulation of RUNX3 expression and activity / negative regulation of protein kinase activity / protein destabilization / RING-type E3 ubiquitin transferase / establishment of protein localization / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / Oncogene Induced Senescence / Regulation of TP53 Activity through Methylation / response to toxic substance / cellular response to gamma radiation / cellular response to growth factor stimulus / cellular response to hydrogen peroxide / protein polyubiquitination / ubiquitin-protein transferase activity / endocytic vesicle membrane / intrinsic apoptotic signaling pathway in response to DNA damage / ubiquitin protein ligase activity / disordered domain specific binding / Signaling by ALK fusions and activated point mutants / Regulation of TP53 Degradation / p53 binding / positive regulation of proteasomal ubiquitin-dependent protein catabolic process Similarity search - Function
E3 ubiquitin-protein ligase Mdm2 / MDM2, modified RING finger, HC subclass / p53 negative regulator Mdm2/Mdm4 / SWIB/MDM2 domain / SWIB/MDM2 domain / SWIB/MDM2 domain profile. / SWIB/MDM2 domain superfamily / Zn-finger in Ran binding protein and others / Zinc finger, C3HC4 type (RING finger) / Zinc finger RanBP2 type profile. ...E3 ubiquitin-protein ligase Mdm2 / MDM2, modified RING finger, HC subclass / p53 negative regulator Mdm2/Mdm4 / SWIB/MDM2 domain / SWIB/MDM2 domain / SWIB/MDM2 domain profile. / SWIB/MDM2 domain superfamily / Zn-finger in Ran binding protein and others / Zinc finger, C3HC4 type (RING finger) / Zinc finger RanBP2 type profile. / Zinc finger RanBP2-type signature. / Zinc finger, RanBP2-type superfamily / Zinc finger, RanBP2-type / 14-3-3 protein sigma / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type Similarity search - Domain/homology
Mass: 3839.950 Da / Num. of mol.: 1 / Source method: obtained synthetically Details: I modified this in order to be able to submit, but please correct the sequence of the peptide: RRRAI(SEP)ETEENSDELSGERQRKRHK(SEP)DSISL Source: (synth.) Homo sapiens (human) References: UniProt: Q00987, RING-type E3 ubiquitin transferase
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