Entry | Database: PDB / ID: 8ou8 |
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Title | Crystal structure of E. coli threonyl tRNA synthetase in complex with a TM84 analogue |
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Components | Threonine--tRNA ligase |
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Keywords | RNA BINDING PROTEIN / threonyl tRNA synthetase / e. coli / inhibitor / complex |
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Function / homology | Function and homology information
threonine-tRNA ligase / threonyl-tRNA aminoacylation / threonine-tRNA ligase activity / tRNA binding / ATP binding / metal ion binding / cytoplasmSimilarity search - Function Threonine-tRNA ligase, class IIa / Threonine-tRNA ligase catalytic core domain / Threonyl/alanyl tRNA synthetase, SAD / Threonyl and Alanyl tRNA synthetase second additional domain / Threonyl and Alanyl tRNA synthetase second additional domain / : / TGS domain / Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily / TGS domain profile. / TGS ...Threonine-tRNA ligase, class IIa / Threonine-tRNA ligase catalytic core domain / Threonyl/alanyl tRNA synthetase, SAD / Threonyl and Alanyl tRNA synthetase second additional domain / Threonyl and Alanyl tRNA synthetase second additional domain / : / TGS domain / Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily / TGS domain profile. / TGS / TGS-like / Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) / tRNA synthetase class II core domain (G, H, P, S and T) / Anticodon-binding / Anticodon binding domain / Anticodon-binding domain superfamily / Aminoacyl-tRNA synthetase, class II / Aminoacyl-transfer RNA synthetases class-II family profile. / Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) / Beta-grasp domain superfamilySimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Escherichia coli IAI1 (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.05 Å |
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Authors | Rodriguez Buitrago, J.A. / Parisini, E. / Aigars, J. |
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Funding support | European Union, 1items Organization | Grant number | Country |
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European Regional Development Fund | 1.1.1.1/19/A/019 | European Union |
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Citation | Journal: Org.Biomol.Chem. / Year: 2023 Title: Synthesis and evaluation of an agrocin 84 toxic moiety (TM84) analogue as a malarial threonyl tRNA synthetase inhibitor. Authors: Buitrago, J.A.R. / Leitis, G. / Kanepe-Lapsa, I. / Rudnickiha, A. / Parisini, E. / Jirgensons, A. |
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History | Deposition | Apr 22, 2023 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jul 12, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 19, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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Revision 1.2 | Sep 6, 2023 | Group: Data collection Category: chem_comp_atom / chem_comp_bond / pdbx_validate_planes Item: _pdbx_validate_planes.type |
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