Entry | Database: PDB / ID: 8osb |
---|
Title | TWIST1-TCF4-ALX4 complex on specific DNA |
---|
Components | - (DNA (25-MER)) x 2
- Homeobox protein aristaless-like 4
- Transcription factor 4
- Twist-related protein 1
|
---|
Keywords | TRANSCRIPTION / transcription factor / complex with DNA |
---|
Function / homology | Function and homology information
embryonic camera-type eye formation / cell proliferation involved in heart valve development / positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation / negative regulation of peroxisome proliferator activated receptor signaling pathway / cranial suture morphogenesis / HMG box domain binding / negative regulation of double-strand break repair / negative regulation of skeletal muscle tissue development / positive regulation of DNA-templated transcription initiation / negative regulation of striated muscle tissue development ...embryonic camera-type eye formation / cell proliferation involved in heart valve development / positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation / negative regulation of peroxisome proliferator activated receptor signaling pathway / cranial suture morphogenesis / HMG box domain binding / negative regulation of double-strand break repair / negative regulation of skeletal muscle tissue development / positive regulation of DNA-templated transcription initiation / negative regulation of striated muscle tissue development / protein-DNA complex assembly / beta-catenin-TCF7L2 complex / negative regulation of macrophage cytokine production / cardiac neural crest cell migration involved in outflow tract morphogenesis / bHLH transcription factor binding / beta-catenin-TCF complex / embryonic skeletal system morphogenesis / mitral valve morphogenesis / developmental process / Transcriptional regulation by RUNX2 / positive regulation of fatty acid beta-oxidation / positive regulation of transcription regulatory region DNA binding / regulation of bone mineralization / embryonic cranial skeleton morphogenesis / digestive tract development / positive regulation of monocyte chemotactic protein-1 production / embryonic forelimb morphogenesis / aortic valve morphogenesis / outer ear morphogenesis / embryonic hindlimb morphogenesis / positive regulation of cell motility / muscle organ development / anterior/posterior pattern specification / endocardial cushion morphogenesis / DNA-binding transcription repressor activity / embryonic digit morphogenesis / roof of mouth development / Myogenesis / eyelid development in camera-type eye / E-box binding / negative regulation of cellular senescence / negative regulation of DNA damage response, signal transduction by p53 class mediator / TFIIB-class transcription factor binding / negative regulation of tumor necrosis factor production / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / hair follicle development / negative regulation of osteoblast differentiation / cis-regulatory region sequence-specific DNA binding / Nuclear events stimulated by ALK signaling in cancer / positive regulation of epithelial to mesenchymal transition / energy homeostasis / positive regulation of neuron differentiation / ossification / negative regulation of miRNA transcription / post-embryonic development / positive regulation of epithelial cell proliferation / skeletal system development / neural tube closure / transcription coregulator binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / neuron migration / cellular response to growth factor stimulus / beta-catenin binding / histone deacetylase binding / osteoblast differentiation / positive regulation of angiogenesis / Regulation of RUNX2 expression and activity / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / sequence-specific double-stranded DNA binding / rhythmic process / nervous system development / cellular response to hypoxia / DNA-binding transcription activator activity, RNA polymerase II-specific / regulation of apoptotic process / Interleukin-4 and Interleukin-13 signaling / DNA-binding transcription factor binding / in utero embryonic development / transcription regulator complex / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / positive regulation of cell migration / protein heterodimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / protein domain specific binding / negative regulation of DNA-templated transcription / positive regulation of gene expression / chromatin / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / identical protein binding / nucleusSimilarity search - Function : / : / : / : / OAR domain / OAR motif / OAR domain profile. / Helix-loop-helix DNA-binding domain / Homeobox, conserved site / 'Homeobox' domain signature. ...: / : / : / : / OAR domain / OAR motif / OAR domain profile. / Helix-loop-helix DNA-binding domain / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Homeobox-like domain superfamilySimilarity search - Domain/homology |
---|
Biological species | Homo sapiens (human) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.9 Å |
---|
Authors | Morgunova, E. / Kim, S. / Popov, A. / Wysocka, J. / Taipale, J. |
---|
Funding support | 1items Organization | Grant number | Country |
---|
Not funded | | |
|
---|
Citation | Journal: Cell / Year: 2024 Title: DNA-guided transcription factor cooperativity shapes face and limb mesenchyme. Authors: Kim, S. / Morgunova, E. / Naqvi, S. / Goovaerts, S. / Bader, M. / Koska, M. / Popov, A. / Luong, C. / Pogson, A. / Swigut, T. / Claes, P. / Taipale, J. / Wysocka, J. |
---|
History | Deposition | Apr 18, 2023 | Deposition site: PDBE / Processing site: PDBE |
---|
Revision 1.0 | Jan 31, 2024 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Feb 7, 2024 | Group: Database references / Category: citation Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_PubMed / _citation.title |
---|
Revision 1.2 | Feb 14, 2024 | Group: Database references / Category: citation / Item: _citation.journal_volume / _citation.page_first |
---|
|
---|