Evidence: homology, This is single whole molecule of human insulin analogue that consists of chain A and chain B that inter-linked by inter-chain disulphide bonds A7-B7 and A20-B19. There is one A ...Evidence: homology, This is single whole molecule of human insulin analogue that consists of chain A and chain B that inter-linked by inter-chain disulphide bonds A7-B7 and A20-B19. There is one A chain intra-chain disulphide A6-A11 as well.
Type
Name
Symmetry operation
Number
identity operation
1_555
x,y,z
1
Buried area
1490 Å2
ΔGint
-24 kcal/mol
Surface area
3580 Å2
Unit cell
Length a, b, c (Å)
57.970, 57.970, 55.820
Angle α, β, γ (deg.)
90.00, 90.00, 90.00
Int Tables number
97
Space group name H-M
I422
Components on special symmetry positions
ID
Model
Components
1
1
A-102-
SO4
2
1
B-101-
IPH
-
Components
#1: Protein/peptide
InsulinAchain
Mass: 2383.698 Da / Num. of mol.: 1 / Source method: obtained synthetically Details: This is insulin analogue chain A with the same sequence as wild type human insulin Source: (synth.) Homo sapiens (human) / References: UniProt: P01308
#2: Protein/peptide
InsulinBchain
Mass: 2955.392 Da / Num. of mol.: 1 / Source method: obtained synthetically Details: This is modified B chain of insulin analogue where wild type B26Tyr is replaced by HYP (trans-hydroxy-proline) and the last B27-B30 residues are deleted. Source: (synth.) Homo sapiens (human) / References: UniProt: P01308