- PDB-8ok0: Crystal structure of human NQO1 in complex with the inhibitor PMSF -
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Basic information
Entry
Database: PDB / ID: 8ok0
Title
Crystal structure of human NQO1 in complex with the inhibitor PMSF
Components
NAD(P)H dehydrogenase [quinone] 1
Keywords
FLAVOPROTEIN / Human NQO1 / flavoenzyme / cancer / inhibitors / PMSF
Function / homology
Function and homology information
response to L-glutamine / response to flavonoid / ubiquinone metabolic process / vitamin E metabolic process / vitamin K metabolic process / NADPH dehydrogenase (quinone) activity / NAD(P)H dehydrogenase (quinone) / cellular response to metal ion / NADH oxidation / cytochrome-b5 reductase activity, acting on NAD(P)H ...response to L-glutamine / response to flavonoid / ubiquinone metabolic process / vitamin E metabolic process / vitamin K metabolic process / NADPH dehydrogenase (quinone) activity / NAD(P)H dehydrogenase (quinone) / cellular response to metal ion / NADH oxidation / cytochrome-b5 reductase activity, acting on NAD(P)H / NADPH oxidation / response to tetrachloromethane / NADH:ubiquinone reductase (non-electrogenic) activity / NAD(P)H dehydrogenase (quinone) activity / response to hydrogen sulfide / response to alkaloid / response to carbohydrate / synaptic transmission, cholinergic / Regulation of ornithine decarboxylase (ODC) / NFE2L2 regulating anti-oxidant/detoxification enzymes / response to testosterone / response to amine / superoxide dismutase activity / response to electrical stimulus / nitric oxide biosynthetic process / removal of superoxide radicals / xenobiotic metabolic process / response to nutrient / cell redox homeostasis / response to hormone / response to ischemia / protein catabolic process / negative regulation of protein catabolic process / response to toxic substance / cellular response to hydrogen peroxide / protein polyubiquitination / positive regulation of neuron apoptotic process / response to estradiol / cellular response to oxidative stress / response to ethanol / response to oxidative stress / response to lipopolysaccharide / innate immune response / neuronal cell body / synapse / dendrite / negative regulation of apoptotic process / RNA binding / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function
Mass: 30778.432 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Details: The sequence is correct and the FAD, PMS, GOL and ACE, belong to HETATM and should not be included in the sequence of the protein. So the system is doing something wrong. Source: (gene. exp.) Homo sapiens (human) / Gene: NQO1 / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P15559