登録情報 | データベース: PDB / ID: 8k62 |
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タイトル | Crystal structure of ALKBH1 and 13h complex. |
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要素 | Nucleic acid dioxygenase ALKBH1 |
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キーワード | DNA BINDING PROTEIN / inhibitor / DNA 6mA demethylase / complex |
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機能・相同性 | 機能・相同性情報
positive regulation of gene expression, epigenetic / regulation of translational initiation by tRNA modification / DNA N6-methyladenine demethylase / DNA N6-methyladenine demethylase activity / regulation of translational elongation / tRNA demethylase activity / oxidative RNA demethylation / regulation of mitochondrial translation / tRNA wobble cytosine modification / DNA oxidative demethylase ...positive regulation of gene expression, epigenetic / regulation of translational initiation by tRNA modification / DNA N6-methyladenine demethylase / DNA N6-methyladenine demethylase activity / regulation of translational elongation / tRNA demethylase activity / oxidative RNA demethylation / regulation of mitochondrial translation / tRNA wobble cytosine modification / DNA oxidative demethylase / oxidative RNA demethylase activity / broad specificity oxidative DNA demethylase activity / 酸化還元酵素; 電子対供与作用を持つ; 分子酸素を取り込むないしは分子酸素を還元する; 2-オキソグルタル酸類を片方の電子供与体とする; 酸素分をそれぞれの電子供与体に取り込む / RNA repair / 2-oxoglutarate-dependent dioxygenase activity / DNA alkylation repair / regulation of translational initiation / chemoattractant activity / developmental growth / class I DNA-(apurinic or apyrimidinic site) endonuclease activity / DNA-(apurinic or apyrimidinic site) lyase / neuron migration / ferrous iron binding / euchromatin / placenta development / neuron projection development / in utero embryonic development / negative regulation of neuron apoptotic process / tRNA binding / DNA repair / endoplasmic reticulum / mitochondrion / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 Alkylated DNA repair protein AlkB / Alpha-ketoglutarate-dependent dioxygenase AlkB-like / 2OG-Fe(II) oxygenase superfamily / Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily / Oxoglutarate/iron-dependent dioxygenase / Fe(2+) 2-oxoglutarate dioxygenase domain profile.類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.991 Å |
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データ登録者 | Liang, X. / Yinping, G. / Feng, L. / Jiang, Z. / Ke, X. / Shengyong, Y. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 81930125 | 中国 |
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引用 | ジャーナル: To Be Published タイトル: Crystal structure of ALKBH1 and 13h complex 著者: Liang, X. / Yinping, G. / Ke, X. / Shengyong, Y. |
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履歴 | 登録 | 2023年7月24日 | 登録サイト: PDBJ / 処理サイト: PDBC |
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改定 1.0 | 2024年7月31日 | Provider: repository / タイプ: Initial release |
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