Entry Database : PDB / ID : 8k4f Structure visualization Downloads & linksTitle DHODH in complex with compound A0 ComponentsDihydroorotate dehydrogenase (quinone), mitochondrial Details Keywords OXIDOREDUCTASE / Inhibitor / complexFunction / homology Function and homology informationFunction Domain/homology Component
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ... pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / plasma membrane / cytosol Similarity search - Function Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase-type TIM barrel Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.48 Å DetailsAuthors Jian, L. / Sun, Q. Funding support China, 1items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) 82273850 China
CitationJournal : J.Med.Chem. / Year : 2023Title : Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease.Authors: Zhou, X. / Gou, K. / Xu, J. / Jian, L. / Luo, Y. / Li, C. / Guan, X. / Qiu, J. / Zou, J. / Zhang, Y. / Zhong, X. / Zeng, T. / Zhou, Y. / Xiao, Y. / Yang, X. / Chen, W. / Gao, P. / Liu, C. / ... Authors : Zhou, X. / Gou, K. / Xu, J. / Jian, L. / Luo, Y. / Li, C. / Guan, X. / Qiu, J. / Zou, J. / Zhang, Y. / Zhong, X. / Zeng, T. / Zhou, Y. / Xiao, Y. / Yang, X. / Chen, W. / Gao, P. / Liu, C. / Zhou, Y. / Tao, L. / Liu, X. / Cen, X. / Chen, Q. / Sun, Q. / Luo, Y. / Zhao, Y. History Deposition Jul 18, 2023 Deposition site : PDBJ / Processing site : PDBCRevision 1.0 May 29, 2024 Provider : repository / Type : Initial release