登録情報 | データベース: PDB / ID: 8j1k |
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タイトル | co-crystal structure of non-carboxylic acid inhibitor with PHD2 |
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要素 | Egl nine homolog 1 |
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キーワード | OXIDOREDUCTASE/INHIBITOR / OXIDOREDUCTASE-INHIBITOR COMPLEX |
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機能・相同性 | 機能・相同性情報
peptidyl-proline 4-dioxygenase activity / hypoxia-inducible factor-proline dioxygenase activity / hypoxia-inducible factor-proline dioxygenase / negative regulation of hypoxia-inducible factor-1alpha signaling pathway / peptidyl-proline dioxygenase activity / regulation protein catabolic process at postsynapse / intracellular oxygen homeostasis / labyrinthine layer development / regulation of modification of postsynaptic structure / heart trabecula formation ...peptidyl-proline 4-dioxygenase activity / hypoxia-inducible factor-proline dioxygenase activity / hypoxia-inducible factor-proline dioxygenase / negative regulation of hypoxia-inducible factor-1alpha signaling pathway / peptidyl-proline dioxygenase activity / regulation protein catabolic process at postsynapse / intracellular oxygen homeostasis / labyrinthine layer development / regulation of modification of postsynaptic structure / heart trabecula formation / 2-oxoglutarate-dependent dioxygenase activity / cardiac muscle tissue morphogenesis / L-ascorbic acid binding / response to nitric oxide / ventricular septum morphogenesis / regulation of neuron apoptotic process / enzyme inhibitor activity / regulation of angiogenesis / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / ferrous iron binding / cellular response to hypoxia / intracellular iron ion homeostasis / response to hypoxia / postsynaptic density / intracellular membrane-bounded organelle / glutamatergic synapse / enzyme binding / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 : / Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain / 2OG-Fe(II) oxygenase superfamily / Prolyl 4-hydroxylase, alpha subunit / Prolyl 4-hydroxylase alpha subunit homologues. / MYND finger / Zinc finger MYND-type signature. / Zinc finger, MYND-type / Zinc finger MYND-type profile. / Oxoglutarate/iron-dependent dioxygenase / Fe(2+) 2-oxoglutarate dioxygenase domain profile.類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.451 Å |
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データ登録者 | Xu, J. / Fu, Y. / Ding, X. / Meng, Q. / Wang, L. / Zhang, M. / Ding, X. / Ren, F. / Zhavoronkov, A. |
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資金援助 | 1件 |
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引用 | ジャーナル: To Be Published タイトル: co-crystal structure of non-carboxylic acid inhibitor with PHD2 著者: Xu, J. / Fu, Y. / Ding, X. / Meng, Q. / Wang, L. / Man, Z. / Ding, X. / Ren, F. / Zhavoronkov, A. |
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履歴 | 登録 | 2023年4月13日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2024年4月17日 | Provider: repository / タイプ: Initial release |
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