Entry Database : PDB / ID : 8j1i Structure visualization Downloads & linksTitle Crystal Structure of EphA8/SASH1 Complex ComponentsEphrin type-A receptor 8 SAM and SH3 domain-containing protein 1 DetailsKeywords SIGNALING PROTEIN / Complex / SAM-SAM / EphA8 receptor / SASH1Function / homology Function and homology informationFunction Domain/homology Component
regulation of protein K63-linked ubiquitination / regulation of protein autoubiquitination / EPH-Ephrin signaling / EPHA-mediated growth cone collapse / substrate-dependent cell migration / EPH-ephrin mediated repulsion of cells / transmembrane-ephrin receptor activity / regulation of epithelial cell migration / GPI-linked ephrin receptor activity / cellular response to follicle-stimulating hormone stimulus ... regulation of protein K63-linked ubiquitination / regulation of protein autoubiquitination / EPH-Ephrin signaling / EPHA-mediated growth cone collapse / substrate-dependent cell migration / EPH-ephrin mediated repulsion of cells / transmembrane-ephrin receptor activity / regulation of epithelial cell migration / GPI-linked ephrin receptor activity / cellular response to follicle-stimulating hormone stimulus / positive regulation of lipopolysaccharide-mediated signaling pathway / ephrin receptor activity / mitogen-activated protein kinase kinase kinase binding / positive regulation of p38MAPK cascade / neuron remodeling / growth factor binding / regulation of cell adhesion mediated by integrin / G-protein alpha-subunit binding / ephrin receptor signaling pathway / regulation of cell adhesion / positive regulation of endothelial cell migration / axon guidance / receptor protein-tyrosine kinase / positive regulation of non-canonical NF-kappaB signal transduction / protein polyubiquitination / positive regulation of angiogenesis / neuron projection development / early endosome membrane / positive regulation of MAPK cascade / protein autophosphorylation / molecular adaptor activity / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell adhesion / neuron projection / dendrite / protein kinase binding / protein-containing complex / nucleoplasm / ATP binding / membrane / plasma membrane / cytosol / cytoplasm Similarity search - Function Ephrin type-A receptor 8, ligand binding domain / SAM and SH3 domain-containing protein 1, SH3 domain / SASH1, SAM domain repeat 1 / SASH1, SAM domain repeat 2 / SAM/SH3 domain-containing / SLy Proteins Associated Disordered Region / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain ... Ephrin type-A receptor 8, ligand binding domain / SAM and SH3 domain-containing protein 1, SH3 domain / SASH1, SAM domain repeat 1 / SASH1, SAM domain repeat 2 / SAM/SH3 domain-containing / SLy Proteins Associated Disordered Region / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain / Ephrin type-A receptor 2 transmembrane domain / Receptor tyrosine kinase class V signature 1. / Receptor tyrosine kinase class V signature 2. / Eph receptor ligand-binding domain profile. / Ephrin receptor ligand binding domain / Putative ephrin-receptor like / Variant SH3 domain / SAM domain (Sterile alpha motif) / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / EGF-like domain signature 2. / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Galactose-binding-like domain superfamily / Fibronectin type III / Fibronectin type III superfamily / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.6 Å DetailsAuthors Liu, W. / Li, J. / Ding, Y. Funding support China, 1items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) China
CitationJournal : To Be Published Title : Structure of EphA8 and SASH1 complex at 1.60 Angstroms resolutionAuthors : Liu, W. / Li, J. / Ding, Y. History Deposition Apr 12, 2023 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Feb 28, 2024 Provider : repository / Type : Initial release