- PDB-8iql: Structural basis of the specificity and interaction mechanism of ... -
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Open data
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Basic information
Entry
Database: PDB / ID: 8iql
Title
Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins
Components
Apoptosis regulator Bcl-2
Bcl-2-modifying factor
Keywords
APOPTOSIS / Complex
Function / homology
Function and homology information
Activation of BMF and translocation to mitochondria / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / myosin complex / anoikis / positive regulation of release of cytochrome c from mitochondria / negative regulation of autophagy / positive regulation of protein-containing complex assembly / cellular response to UV / mitochondrial outer membrane / positive regulation of apoptotic process ...Activation of BMF and translocation to mitochondria / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / myosin complex / anoikis / positive regulation of release of cytochrome c from mitochondria / negative regulation of autophagy / positive regulation of protein-containing complex assembly / cellular response to UV / mitochondrial outer membrane / positive regulation of apoptotic process / plasma membrane / cytosol Similarity search - Function
Mass: 19357.557 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli)
#2: Protein/peptide
Bcl-2-modifyingfactor
Mass: 3003.440 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: BMF / Production host: Escherichia coli (E. coli) / References: UniProt: Q96LC9
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 4.2 Å3/Da / Density % sol: 70.73 %
Crystal grow
Temperature: 291 K / Method: vapor diffusion, hanging drop Details: 0.1 M potassium thiocyanate, polyethylene glycol monomethyl ether 2,000
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Data collection
Diffraction
Mean temperature: 100 K / Serial crystal experiment: N
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