PROTEIN FIBRIL / Necroptosis / RIPK1 / RHIM / SSNMR
Function / homology
Function and homology information
: / : / TNF signaling / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / RIPK1-mediated regulated necrosis / Caspase activation via Death Receptors in the presence of ligand / TRIF-mediated programmed cell death / TNFR1-induced proapoptotic signaling ...: / : / TNF signaling / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / RIPK1-mediated regulated necrosis / Caspase activation via Death Receptors in the presence of ligand / TRIF-mediated programmed cell death / TNFR1-induced proapoptotic signaling / regulation of ATP:ADP antiporter activity / ripoptosome assembly / positive regulation of interleukin-6-mediated signaling pathway / : / ripoptosome assembly involved in necroptotic process / death domain binding / TNFR1-induced NF-kappa-B signaling pathway / IKK complex recruitment mediated by RIP1 / Regulation of TNFR1 signaling / Regulation of necroptotic cell death / Ovarian tumor domain proteases / ripoptosome / cell death / programmed necrotic cell death / T cell apoptotic process / positive regulation of macrophage differentiation / necroptotic signaling pathway / TRP channels / JUN kinase kinase kinase activity / peptidyl-serine autophosphorylation / positive regulation of necroptotic process / Ub-specific processing proteases / death-inducing signaling complex / negative regulation of necroptotic process / positive regulation of tumor necrosis factor-mediated signaling pathway / death receptor binding / positive regulation of extrinsic apoptotic signaling pathway / positive regulation of programmed cell death / regulation of reactive oxygen species metabolic process / necroptotic process / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / response to tumor necrosis factor / extrinsic apoptotic signaling pathway / negative regulation of canonical NF-kappaB signal transduction / positive regulation of phosphorylation / positive regulation of interleukin-8 production / negative regulation of extrinsic apoptotic signaling pathway / positive regulation of JNK cascade / protein catabolic process / cellular response to growth factor stimulus / cellular response to hydrogen peroxide / positive regulation of inflammatory response / positive regulation of tumor necrosis factor production / cellular response to tumor necrosis factor / positive regulation of NF-kappaB transcription factor activity / positive regulation of canonical NF-kappaB signal transduction / amyloid fibril formation / positive regulation of MAPK cascade / protein autophosphorylation / receptor complex / non-specific serine/threonine protein kinase / protein kinase activity / inflammatory response / positive regulation of protein phosphorylation / positive regulation of apoptotic process / membrane raft / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / ubiquitin protein ligase binding / positive regulation of gene expression / protein-containing complex binding / negative regulation of apoptotic process / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / mitochondrion / ATP binding / identical protein binding Similarity search - Function
RHIM domain / RIP1, Death domain / RIP homotypic interaction motif / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain ...RHIM domain / RIP1, Death domain / RIP homotypic interaction motif / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homology
1 mg/mL protein elution solution was dialyzed for 4 days using 3.5-kDa dialysis membranes in Milli-Q water (pH 7.5) at room temperature, water was replaced twice every 24 h.
0mM
conditions_1
7.5
1atm
303K
2
1 mg/mL protein elution solution was dialyzed for 4 days using 3.5-kDa dialysis membranes in Milli-Q water (pH 7.5) at room temperature, water was replaced twice every 24 h.
0mM
conditions_2
7.5
1Pa
279K
3
1:1 mixing protein elution solution was dialyzed for 4 days using 3.5-kDa dialysis membranes in Milli-Q water (pH 7.5) at room temperature, water was replaced twice every 24 h.
0mM
conditions_3
7.5
1Pa
271K
-
NMR measurement
NMR spectrometer
Type
Manufacturer
Model
Field strength (MHz)
Spectrometer-ID
Bruker 3.2 mm HCN E free probe
Bruker
3.2mmHCNEfreeprobe
700
1
Bruker 0.7 mm HCN probe
Bruker
0.7mmHCNprobe
700
2
-
Processing
NMR software
Name
Developer
Classification
TopSpin
BrukerBiospin
collection
Sparky
Goddard
dataanalysis
X-PLOR NIH
Schwieters, Kuszewski, TjandraandClore
structurecalculation
X-PLOR NIH
Schwieters, Kuszewski, TjandraandClore
refinement
Refinement
Method: simulated annealing / Software ordinal: 3
NMR representative
Selection criteria: lowest energy
NMR ensemble
Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 196 / Conformers submitted total number: 10
+
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