登録情報 データベース : PDB / ID : 8i2b 構造の表示 ダウンロードとリンクタイトル Human SIRT6 in complex with inhibitor 7702 要素NAD-dependent protein deacylase sirtuin-6 詳細 キーワード LYASE/INHIBITOR / LYASE-INHIBITOR COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
histone H3K56 deacetylase activity, NAD-dependent / ketone biosynthetic process / histone H3K18 deacetylase activity, NAD-dependent / histone H3K9 deacetylase activity, hydrolytic mechanism / histone H3K9 deacetylase activity, NAD-dependent / protein delipidation / NAD+-protein-lysine ADP-ribosyltransferase activity / regulation of lipid catabolic process / chromosome, subtelomeric region / positive regulation of protein localization to chromatin ... histone H3K56 deacetylase activity, NAD-dependent / ketone biosynthetic process / histone H3K18 deacetylase activity, NAD-dependent / histone H3K9 deacetylase activity, hydrolytic mechanism / histone H3K9 deacetylase activity, NAD-dependent / protein delipidation / NAD+-protein-lysine ADP-ribosyltransferase activity / regulation of lipid catabolic process / chromosome, subtelomeric region / positive regulation of protein localization to chromatin / NAD-dependent protein demyristoylase activity / NAD-dependent protein depalmitoylase activity / NAD+-protein-arginine ADP-ribosyltransferase activity / DNA damage sensor activity / positive regulation of stem cell differentiation / negative regulation of D-glucose import / NAD-dependent protein lysine deacetylase activity / positive regulation of chondrocyte proliferation / transposable element silencing / protein acetyllysine N-acetyltransferase / cardiac muscle cell differentiation / pericentric heterochromatin formation / protein deacetylation / histone deacetylase activity, NAD-dependent / protein localization to site of double-strand break / positive regulation of blood vessel branching / negative regulation of glycolytic process / negative regulation of protein localization to chromatin / TORC2 complex binding / positive regulation of vascular endothelial cell proliferation / histone deacetylase regulator activity / regulation of double-strand break repair via homologous recombination / positive regulation of double-strand break repair / negative regulation of protein import into nucleus / regulation of protein secretion / lncRNA binding / DNA repair-dependent chromatin remodeling / negative regulation of gene expression, epigenetic / positive regulation of stem cell proliferation / positive regulation of stem cell population maintenance / NAD+-protein mono-ADP-ribosyltransferase activity / positive regulation of telomere maintenance / pericentric heterochromatin / site of DNA damage / regulation of lipid metabolic process / NAD+ poly-ADP-ribosyltransferase activity / negative regulation of transcription elongation by RNA polymerase II / negative regulation of cellular senescence / 転移酵素; グリコシル基を移すもの; 五炭糖残基を移すもの / NAD+ binding / positive regulation of fat cell differentiation / negative regulation of gluconeogenesis / subtelomeric heterochromatin formation / regulation of protein localization to plasma membrane / response to UV / nucleosome binding / enzyme regulator activity / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / nucleotidyltransferase activity / positive regulation of protein export from nucleus / determination of adult lifespan / chromatin DNA binding / circadian regulation of gene expression / regulation of circadian rhythm / protein destabilization / base-excision repair / positive regulation of insulin secretion / Pre-NOTCH Transcription and Translation / positive regulation of fibroblast proliferation / protein import into nucleus / transcription corepressor activity / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / glucose homeostasis / site of double-strand break / double-strand break repair / Processing of DNA double-strand break ends / positive regulation of cold-induced thermogenesis / damaged DNA binding / chromatin remodeling / negative regulation of cell population proliferation / intracellular membrane-bounded organelle / chromatin binding / chromatin / endoplasmic reticulum / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / DNA binding / zinc ion binding / nucleoplasm / nucleus 類似検索 - 分子機能 Sirtuin family / : / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / DHS-like NAD/FAD-binding domain superfamily 類似検索 - ドメイン・相同性 Chem-AR6 / Chem-O5L / NAD-dependent protein deacylase sirtuin-6 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.2 Å 詳細データ登録者 Wang, Y. 資金援助 中国, 1件 詳細 詳細を隠す組織 認可番号 国 National Natural Science Foundation of China (NSFC) 21977121 中国
引用ジャーナル : Acta Pharm Sin B / 年 : 2024タイトル : Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo.著者 : Xu, X. / Zhang, Q. / Wang, X. / Jin, J. / Wu, C. / Feng, L. / Yang, X. / Zhao, M. / Chen, Y. / Lu, S. / Zheng, Z. / Lan, X. / Wang, Y. / Zheng, Y. / Lu, X. / Zhang, Q. / Zhang, J. 履歴 登録 2023年1月14日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2024年1月17日 Provider : repository / タイプ : Initial release改定 1.1 2025年7月30日 Group : Database references / Derived calculations / Structure summaryカテゴリ : chem_comp / citation ... chem_comp / citation / citation_author / entity / pdbx_entity_nonpoly / pdbx_entry_details Item : _chem_comp.name / _citation.country ... _chem_comp.name / _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_entry_details.has_protein_modification
すべて表示 表示を減らす