登録情報 データベース : PDB / ID : 8i0p 構造の表示 ダウンロードとリンクタイトル The cryo-EM structure of human pre-Bact complex 要素(Pre-mRNA-splicing factor ...) x 2 (Small nuclear ribonucleoprotein ...) x 6 (Splicing factor 3A subunit ...) x 3 (Splicing factor 3B subunit ...) x 6 (U2 small nuclear ribonucleoprotein ...) x 2 (U5 small nuclear ribonucleoprotein ...) x 2 116 kDa U5 small nuclear ribonucleoprotein component BUD13 homolog Cell division cycle 5-like protein Crooked neck-like protein 1 DNA/RNA-binding protein KIN17 PHD finger-like domain-containing protein 5A Peptidyl-prolyl cis-trans isomerase E Pleiotropic regulator 1 Pre-mRNA-processing-splicing factor 8 Protein BUD31 homolog RING-type E3 ubiquitin-protein ligase PPIL2 RNA helicase aquarius RNA-binding motif protein, X-linked 2 SNW domain-containing protein 1 Serine/arginine repetitive matrix protein 1 Smad nuclear-interacting protein 1 Small nuclear ribonucleoprotein-associated proteins B and B' Spliceosome-associated protein CWC15 homolog U2 snRNA U5 snRNA U6 snRNA Unknown polymer pre-mRNA 残り25件を表示 表示を減らす 詳細キーワード SPLICING / spliceosome / pre-Bact complex / RNA splicing / PRP2 / activation機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RES complex / U11/U12 snRNP / post-mRNA release spliceosomal complex / regulation of retinoic acid receptor signaling pathway / 3'-5' RNA helicase activity / U2 snRNP binding / U7 snRNA binding / histone pre-mRNA DCP binding / generation of catalytic spliceosome for first transesterification step / U7 snRNP ... RES complex / U11/U12 snRNP / post-mRNA release spliceosomal complex / regulation of retinoic acid receptor signaling pathway / 3'-5' RNA helicase activity / U2 snRNP binding / U7 snRNA binding / histone pre-mRNA DCP binding / generation of catalytic spliceosome for first transesterification step / U7 snRNP / B-WICH complex / regulation of vitamin D receptor signaling pathway / histone pre-mRNA 3'end processing complex / cis assembly of pre-catalytic spliceosome / SLBP independent Processing of Histone Pre-mRNAs / SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs / splicing factor binding / spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) / miRNA processing / protein methylation / U12-type spliceosomal complex / methylosome / nuclear retinoic acid receptor binding / Prp19 complex / 7-methylguanosine cap hypermethylation / positive regulation of androgen receptor activity / poly(A) binding / blastocyst formation / U1 snRNP binding / mRNA 3'-end processing / pICln-Sm protein complex / pre-mRNA binding / U2-type catalytic step 1 spliceosome / RNA splicing, via transesterification reactions / small nuclear ribonucleoprotein complex / sno(s)RNA-containing ribonucleoprotein complex / SMN-Sm protein complex / regulation of mRNA splicing, via spliceosome / spliceosomal tri-snRNP complex / P granule / telomerase holoenzyme complex / U2-type spliceosomal complex / mRNA cis splicing, via spliceosome / positive regulation by host of viral transcription / U2-type precatalytic spliceosome / commitment complex / transcription regulator inhibitor activity / Transport of Mature mRNA derived from an Intron-Containing Transcript / positive regulation of vitamin D receptor signaling pathway / telomerase RNA binding / U2-type prespliceosome assembly / nuclear vitamin D receptor binding / U2-type catalytic step 2 spliceosome / U4 snRNP / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / Notch binding / RUNX3 regulates NOTCH signaling / SAGA complex / U2 snRNP / RHOBTB1 GTPase cycle / positive regulation of mRNA splicing, via spliceosome / Basigin interactions / RNA Polymerase II Transcription Termination / NOTCH4 Intracellular Domain Regulates Transcription / positive regulation of transcription by RNA polymerase III / U1 snRNP / ubiquitin-ubiquitin ligase activity / WD40-repeat domain binding / NOTCH3 Intracellular Domain Regulates Transcription / positive regulation of neurogenesis / U2-type prespliceosome / K63-linked polyubiquitin modification-dependent protein binding / cyclosporin A binding / nuclear androgen receptor binding / precatalytic spliceosome / positive regulation of transcription by RNA polymerase I / Notch-HLH transcription pathway / positive regulation of transforming growth factor beta receptor signaling pathway / Formation of paraxial mesoderm / spliceosomal complex assembly / mRNA Splicing - Minor Pathway / regulation of alternative mRNA splicing, via spliceosome / SMAD binding / regulation of RNA splicing / mRNA 3'-splice site recognition / blastocyst development / protein localization to nucleus / localization / spliceosomal tri-snRNP complex assembly / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / retinoic acid receptor signaling pathway / U5 snRNA binding / positive regulation of G1/S transition of mitotic cell cycle / U5 snRNP / RHOBTB2 GTPase cycle / transcription-coupled nucleotide-excision repair / positive regulation of viral genome replication / Protein methylation / RNA processing / U2 snRNA binding 類似検索 - 分子機能 DNA/RNA-binding protein Kin17, WH-like domain / KIN17-like protein / DNA/RNA-binding protein KIN17, WH-like domain superfamily / KN17, SH3-like C-terminal domain / Kin17, KOW domain / Domain of Kin17 curved DNA-binding protein / KN17 SH3-like C-terminal domain / Domain of Kin17 curved DNA-binding protein / Peptidyl-prolyl cis-trans isomerase like 2, U-box domain / : ... DNA/RNA-binding protein Kin17, WH-like domain / KIN17-like protein / DNA/RNA-binding protein KIN17, WH-like domain superfamily / KN17, SH3-like C-terminal domain / Kin17, KOW domain / Domain of Kin17 curved DNA-binding protein / KN17 SH3-like C-terminal domain / Domain of Kin17 curved DNA-binding protein / Peptidyl-prolyl cis-trans isomerase like 2, U-box domain / : / Ist3-like, RNA recognition motif / Bud13 / Pre-mRNA-splicing factor of RES complex / : / : / Intron-binding protein aquarius, beta-barrel / Intron-binding protein aquarius insert domain / CWF11 family / Intron-binding protein aquarius, N-terminal / Intron-binding protein aquarius N-terminal / Peptidyl-prolyl cis-trans isomerase E / Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif / SF3B6, RNA recognition motif / PWI domain superfamily / PWI domain / PWI domain profile. / SF3B4, RNA recognition motif 2 / Splicing factor SF3a60 binding domain / Splicing factor SF3a60 binding domain / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like / Cactus-binding C-terminus of cactin protein / : / Replication stress response SDE2 C-terminal / Splicing factor 3A subunit 1, ubiquitin domain / PWI domain / PWI, domain in splicing factors / SF3A2 domain / : / Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) / STL11, N-terminal / U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 / U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 / Splicing factor SF3a60 /Prp9 subunit, C-terminal / SF3A3 domain / SF3a60/Prp9 C-terminal / Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 / : / SF3B4, RNA recognition motif 1 / DNA2/NAM7 helicase, helicase domain / DNA2/NAM7-like helicase / AAA domain / WD repeat Prp46/PLRG1-like / Splicing factor 3A subunit 1 / Splicing factor 3B, subunit 5 / BUD31/G10-related, conserved site / : / : / : / G10 protein signature 1. / G10 protein signature 2. / SKI-interacting protein SKIP, SNW domain / SKI-interacting protein, SKIP / Splicing factor 3A subunit 1, conserved domain / SKIP/SNW domain / Pre-mRNA splicing factor PRP21 like protein / Myb-like DNA-binding domain / Pre-mRNA-splicing factor Cwf15/Cwc15 / HAT (Half-A-TPR) repeat / Cwf15/Cwc15 cell cycle control protein / Splicing factor 3B subunit 1 / Splicing factor 3B subunit 1 / Domain of unknown function DUF382 / Pre-mRNA-splicing factor Cwc2/Slt11 / Domain of unknown function (DUF382) / G10 protein / Pre-mRNA-splicing factor BUD31 / SWAP/Surp / Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal / SWAP/Surp superfamily / Surp module / pre-mRNA splicing factor component / Zinc-finger of C2H2 type / SURP motif repeat profile. / Suppressor-of-White-APricot splicing regulator / PHF5-like / PHF5-like protein / PSP, proline-rich / PSP / proline-rich domain in spliceosome associated proteins / Splicing factor 3B subunit 5/RDS3 complex subunit 10 / Splicing factor 3B subunit 10 (SF3b10) / Splicing factor 3B subunit 1-like / Small ribonucleoprotein associated, SmB/SmN / Matrin/U1-C, C2H2-type zinc finger / Zinc finger matrin-type profile. / Small nuclear ribonucleoprotein D1 / U-box domain profile. / Modified RING finger domain / U-box domain / U2A'/phosphoprotein 32 family A, C-terminal 類似検索 - ドメイン・相同性 GUANOSINE-5'-TRIPHOSPHATE / : / : / RNA / RNA (> 10) / RNA (> 100) / Pleiotropic regulator 1 / RNA helicase aquarius / DNA/RNA-binding protein KIN17 / Splicing factor 3B subunit 1 ... GUANOSINE-5'-TRIPHOSPHATE / : / : / RNA / RNA (> 10) / RNA (> 100) / Pleiotropic regulator 1 / RNA helicase aquarius / DNA/RNA-binding protein KIN17 / Splicing factor 3B subunit 1 / U5 small nuclear ribonucleoprotein 200 kDa helicase / U2 small nuclear ribonucleoprotein B'' / U2 small nuclear ribonucleoprotein A' / Small nuclear ribonucleoprotein-associated proteins B and B' / Protein BUD31 homolog / Small nuclear ribonucleoprotein E / Small nuclear ribonucleoprotein F / Small nuclear ribonucleoprotein G / Small nuclear ribonucleoprotein Sm D1 / Small nuclear ribonucleoprotein Sm D2 / Small nuclear ribonucleoprotein Sm D3 / Splicing factor 3A subunit 3 / RING-type E3 ubiquitin-protein ligase PPIL2 / Splicing factor 3B subunit 2 / SNW domain-containing protein 1 / 116 kDa U5 small nuclear ribonucleoprotein component / Splicing factor 3B subunit 3 / Splicing factor 3B subunit 4 / Splicing factor 3A subunit 2 / Splicing factor 3A subunit 1 / Pre-mRNA-processing-splicing factor 8 / PHD finger-like domain-containing protein 5A / Serine/arginine repetitive matrix protein 1 / Smad nuclear-interacting protein 1 / U5 small nuclear ribonucleoprotein 40 kDa protein / Cell division cycle 5-like protein / BUD13 homolog / Splicing factor 3B subunit 5 / Crooked neck-like protein 1 / Pre-mRNA-splicing factor SYF1 / Pre-mRNA-splicing factor RBM22 / Spliceosome-associated protein CWC15 homolog / Peptidyl-prolyl cis-trans isomerase E / RNA-binding motif protein, X-linked 2 / Splicing factor 3B subunit 6 類似検索 - 構成要素生物種 Homo sapiens (ヒト) unidentified adenovirus (ウイルス)手法 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 3.4 Å 詳細データ登録者 Zhan, X. / Lu, Y. / Shi, Y. 資金援助 中国, 1件 詳細 詳細を隠す組織 認可番号 国 National Natural Science Foundation of China (NSFC) 中国
引用ジャーナル : To Be Published タイトル : Molecular Basis for the activation of Human spliceosome著者 : Zhan, X. / Lu, Y. / Shi, Y. 履歴 登録 2023年1月11日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2024年7月31日 Provider : repository / タイプ : Initial release