登録情報 | データベース: PDB / ID: 8hst |
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タイトル | The structure of rat beta-arrestin1 |
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要素 | Beta-arrestin-1 |
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キーワード | SIGNALING PROTEIN / Arrestin |
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機能・相同性 | 機能・相同性情報
V2 vasopressin receptor binding / alpha-1A adrenergic receptor binding / follicle-stimulating hormone receptor binding / sensory perception of touch / G alpha (s) signalling events / alpha-1B adrenergic receptor binding / follicle-stimulating hormone signaling pathway / protein phosphorylated amino acid binding / angiotensin receptor binding / Lysosome Vesicle Biogenesis ...V2 vasopressin receptor binding / alpha-1A adrenergic receptor binding / follicle-stimulating hormone receptor binding / sensory perception of touch / G alpha (s) signalling events / alpha-1B adrenergic receptor binding / follicle-stimulating hormone signaling pathway / protein phosphorylated amino acid binding / angiotensin receptor binding / Lysosome Vesicle Biogenesis / AP-2 adaptor complex binding / Golgi Associated Vesicle Biogenesis / MAP2K and MAPK activation / Ub-specific processing proteases / positive regulation of smooth muscle cell apoptotic process / negative regulation of interleukin-8 production / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / clathrin adaptor activity / regulation of G protein-coupled receptor signaling pathway / arrestin family protein binding / G protein-coupled receptor internalization / response to morphine / Thrombin signalling through proteinase activated receptors (PARs) / mitogen-activated protein kinase kinase binding / clathrin binding / positive regulation of Rho protein signal transduction / stress fiber assembly / negative regulation of Notch signaling pathway / pseudopodium / positive regulation of insulin secretion involved in cellular response to glucose stimulus / negative regulation of interleukin-6 production / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / positive regulation of receptor internalization / phototransduction / clathrin-coated pit / negative regulation of protein ubiquitination / visual perception / GTPase activator activity / negative regulation of protein phosphorylation / positive regulation of protein ubiquitination / G protein-coupled receptor binding / nuclear estrogen receptor binding / phosphoprotein binding / insulin-like growth factor receptor binding / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / negative regulation of ERK1 and ERK2 cascade / endocytosis / protein transport / positive regulation of peptidyl-serine phosphorylation / cytoplasmic vesicle / ubiquitin-dependent protein catabolic process / basolateral plasma membrane / postsynaptic membrane / regulation of apoptotic process / proteasome-mediated ubiquitin-dependent protein catabolic process / transmembrane transporter binding / negative regulation of neuron apoptotic process / positive regulation of MAPK cascade / dendritic spine / transcription coactivator activity / positive regulation of ERK1 and ERK2 cascade / protein ubiquitination / endosome / response to xenobiotic stimulus / positive regulation of protein phosphorylation / G protein-coupled receptor signaling pathway / signaling receptor binding / ubiquitin protein ligase binding / positive regulation of cell population proliferation / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Arrestin, conserved site / Arrestins signature. / Arrestin / Arrestin, N-terminal / Arrestin-like, N-terminal / Arrestin C-terminal-like domain / Arrestin (or S-antigen), N-terminal domain / Arrestin (or S-antigen), C-terminal domain / Arrestin (or S-antigen), C-terminal domain / Arrestin-like, C-terminal / Immunoglobulin E-set類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.66 Å |
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データ登録者 | Yun, Y. / Yoon, H.J. / Choi, Y. / Lee, H.H. |
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資金援助 | 韓国, 1件 組織 | 認可番号 | 国 |
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National Research Foundation (NRF, Korea) | | 韓国 |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2023 タイトル: GPCR targeting of E3 ubiquitin ligase MDM2 by inactive beta-arrestin. 著者: Yun, Y. / Yoon, H.J. / Jeong, Y. / Choi, Y. / Jang, S. / Chung, K.Y. / Lee, H.H. |
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履歴 | 登録 | 2022年12月20日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2023年7月19日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年5月29日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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