Entry Database : PDB / ID : 8hoi Structure visualization Downloads & linksTitle Crystal structure of Bcl-2 D103Y in complex with sonrotoclax ComponentsApoptosis regulator Bcl-2 Details Keywords APOPTOSIS / InhibitorFunction / homology Chem-98I / FORMIC ACID Function and homology informationBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.25 Å DetailsAuthors Liu, J. / Xu, M. / Feng, Y. / Hong, Y. / Liu, Y. Funding support 1items Details Hide detailsOrganization Grant number Country Not funded
CitationJournal : Blood / Year : 2024Title : Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.Authors: Liu, J. / Li, S. / Wang, Q. / Feng, Y. / Xing, H. / Yang, X. / Guo, Y. / Guo, Y. / Sun, H. / Liu, X. / Yang, S. / Mei, Z. / Zhu, Y. / Cheng, Z. / Chen, S. / Xu, M. / Zhang, W. / Wan, N. / ... Authors : Liu, J. / Li, S. / Wang, Q. / Feng, Y. / Xing, H. / Yang, X. / Guo, Y. / Guo, Y. / Sun, H. / Liu, X. / Yang, S. / Mei, Z. / Zhu, Y. / Cheng, Z. / Chen, S. / Xu, M. / Zhang, W. / Wan, N. / Wang, J. / Ma, Y. / Zhang, S. / Luan, X. / Xu, A. / Li, L. / Wang, H. / Yang, X. / Hong, Y. / Xue, H. / Yuan, X. / Hu, N. / Song, X. / Wang, Z. / Liu, X. / Wang, L. / Liu, Y. History Deposition Dec 10, 2022 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jan 17, 2024 Provider : repository / Type : Initial releaseRevision 1.1 Jan 31, 2024 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 May 15, 2024 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID
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