登録情報 | データベース: PDB / ID: 8h6d |
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タイトル | Crystal structure of human GCN5 histone acetyltransferase domain bound with glutaryl-CoA |
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要素 | Histone acetyltransferase KAT2A |
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キーワード | TRANSFERASE / Complex |
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機能・相同性 | 機能・相同性情報
histone succinyltransferase activity / peptidyl-lysine glutarylation / histone glutaryltransferase activity / metencephalon development / regulation of cartilage development / positive regulation of cell projection organization / histone H4K12 acetyltransferase activity / histone H3K9 acetyltransferase activity / positive regulation of cardiac muscle cell differentiation / regulation of stem cell population maintenance ...histone succinyltransferase activity / peptidyl-lysine glutarylation / histone glutaryltransferase activity / metencephalon development / regulation of cartilage development / positive regulation of cell projection organization / histone H4K12 acetyltransferase activity / histone H3K9 acetyltransferase activity / positive regulation of cardiac muscle cell differentiation / regulation of stem cell population maintenance / regulation of bone development / negative regulation of centriole replication / regulation of regulatory T cell differentiation / telencephalon development / transcription factor TFTC complex / internal peptidyl-lysine acetylation / histone H3 acetyltransferase activity / histone H3K18 acetyltransferase activity / ATAC complex / Cardiogenesis / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / limb development / RUNX3 regulates NOTCH signaling / regulation of T cell activation / SAGA complex / NOTCH4 Intracellular Domain Regulates Transcription / NOTCH3 Intracellular Domain Regulates Transcription / peptide-lysine-N-acetyltransferase activity / midbrain development / regulation of tubulin deacetylation / intracellular distribution of mitochondria / Formation of WDR5-containing histone-modifying complexes / Notch-HLH transcription pathway / Formation of paraxial mesoderm / regulation of cell division / RNA Polymerase I Transcription Initiation / regulation of RNA splicing / regulation of embryonic development / histone acetyltransferase complex / negative regulation of gluconeogenesis / long-term memory / somitogenesis / regulation of DNA repair / histone acetyltransferase activity / histone acetyltransferase / positive regulation of gluconeogenesis / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / response to nutrient levels / cellular response to nerve growth factor stimulus / positive regulation of cytokine production / neural tube closure / gluconeogenesis / B-WICH complex positively regulates rRNA expression / regulation of protein stability / regulation of synaptic plasticity / multicellular organism growth / response to organic cyclic compound / NOTCH1 Intracellular Domain Regulates Transcription / mitotic spindle / Pre-NOTCH Transcription and Translation / histone deacetylase binding / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / cellular response to tumor necrosis factor / heart development / HATs acetylate histones / protein phosphatase binding / fibroblast proliferation / DNA-binding transcription factor binding / transcription coactivator activity / in utero embryonic development / chromatin remodeling / regulation of cell cycle / Ub-specific processing proteases / chromatin binding / centrosome / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / extracellular space / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 PCAF, N-terminal / Histone acetyltransferase GCN5/PCAF / PCAF (P300/CBP-associated factor) N-terminal domain / Histone acetyltransferase GCN5 / Acetyltransferase (GNAT) family / Gcn5-related N-acetyltransferase (GNAT) domain profile. / GNAT domain / Acyl-CoA N-acyltransferase / Bromodomain, conserved site / Bromodomain signature. ...PCAF, N-terminal / Histone acetyltransferase GCN5/PCAF / PCAF (P300/CBP-associated factor) N-terminal domain / Histone acetyltransferase GCN5 / Acetyltransferase (GNAT) family / Gcn5-related N-acetyltransferase (GNAT) domain profile. / GNAT domain / Acyl-CoA N-acyltransferase / Bromodomain, conserved site / Bromodomain signature. / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Bromodomain類似検索 - ドメイン・相同性 glutaryl-coenzyme A / Histone acetyltransferase KAT2A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.26 Å |
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データ登録者 | Li, N. / Tao, Y.J. / Guo, Y.R. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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Welch Foundation | | 米国 |
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引用 | ジャーナル: Res / 年: 2023 タイトル: Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications. 著者: Li, S. / Li, N. / He, J. / Zhou, R. / Lu, Z. / Tao, Y.J. / Guo, Y.R. / Wang, Y. |
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履歴 | 登録 | 2022年10月16日 | 登録サイト: PDBJ / 処理サイト: RCSB |
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改定 1.0 | 2023年5月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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