Entry | Database: PDB / ID: 8gew |
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Title | H-FABP crystal soaked in a bromo palmitic acid solution |
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Components | Fatty acid-binding protein, heart |
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Keywords | LIPID BINDING PROTEIN / H-FABP / Br-Palmitic acid |
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Function / homology | Function and homology information
positive regulation of long-chain fatty acid import into cell / regulation of phosphatidylcholine biosynthetic process / regulation of fatty acid oxidation / positive regulation of phospholipid biosynthetic process / intracellular lipid transport / oleic acid binding / phospholipid homeostasis / long-chain fatty acid binding / Triglyceride catabolism / long-chain fatty acid transport ...positive regulation of long-chain fatty acid import into cell / regulation of phosphatidylcholine biosynthetic process / regulation of fatty acid oxidation / positive regulation of phospholipid biosynthetic process / intracellular lipid transport / oleic acid binding / phospholipid homeostasis / long-chain fatty acid binding / Triglyceride catabolism / long-chain fatty acid transport / brown fat cell differentiation / cytoskeletal protein binding / cholesterol homeostasis / negative regulation of cell population proliferation / extracellular space / extracellular exosome / nucleus / cytosolSimilarity search - Function Cytosolic fatty-acid binding proteins signature. / Intracellular lipid binding protein / Cytosolic fatty-acid binding / Lipocalin / cytosolic fatty-acid binding protein family / Lipocalin/cytosolic fatty-acid binding domain / CalycinSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 0.97 Å |
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Authors | Howard, E. / Cousido-Siah, A. / Alvarez, A. / Espinosa, Y. / Podjarny, A. / Mitschler, A. / Carlevaro, M. |
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Funding support | Argentina, 1items Organization | Grant number | Country |
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National Scientific and Technical Research Council (CONICET) | 22920180100010 CO | Argentina |
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Citation | Journal: Proteins / Year: 2023 Title: Lipid exchange in crystal-confined fatty acid binding proteins: X-ray evidence and molecular dynamics explanation. Authors: Alvarez, H.A. / Cousido-Siah, A. / Espinosa, Y.R. / Podjarny, A. / Carlevaro, C.M. / Howard, E. |
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History | Deposition | Mar 7, 2023 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Aug 30, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 18, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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Revision 2.0 | Apr 17, 2024 | Group: Atomic model / Author supporting evidence ...Atomic model / Author supporting evidence / Data collection / Refinement description Category: atom_site / atom_site_anisotrop ...atom_site / atom_site_anisotrop / pdbx_entity_instance_feature / pdbx_nonpoly_scheme / refine / refine_hist / refine_ls_restr / refine_ls_shell / reflns / reflns_shell Item: _atom_site.B_iso_or_equiv / _atom_site.calc_flag ..._atom_site.B_iso_or_equiv / _atom_site.calc_flag / _atom_site.label_alt_id / _atom_site.occupancy / _atom_site_anisotrop.U[1][1] / _atom_site_anisotrop.U[1][2] / _atom_site_anisotrop.U[1][3] / _atom_site_anisotrop.U[2][2] / _atom_site_anisotrop.U[2][3] / _atom_site_anisotrop.U[3][3] / _atom_site_anisotrop.pdbx_label_alt_id / _pdbx_nonpoly_scheme.auth_mon_id / _pdbx_nonpoly_scheme.auth_seq_num / _refine.aniso_B[1][3] / _refine.details / _refine.ls_R_factor_R_free / _refine.ls_R_factor_R_work / _refine.ls_R_factor_all / _refine.ls_d_res_high / _refine.ls_number_reflns_R_work / _refine.ls_percent_reflns_obs / _refine.ls_wR_factor_R_free / _refine.ls_wR_factor_R_work / _refine.pdbx_average_fsc_free / _refine.pdbx_average_fsc_work / _refine_hist.d_res_high / _reflns.pdbx_CC_half / _reflns.pdbx_Rpim_I_all / _reflns.pdbx_Rrim_I_all / _reflns.pdbx_chi_squared / _reflns_shell.number_unique_obs / _reflns_shell.pdbx_CC_half / _reflns_shell.pdbx_Rpim_I_all / _reflns_shell.pdbx_chi_squared |
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