登録情報 | データベース: PDB / ID: 8gdy |
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タイトル | Crystal structure of the human PDI first domain with 9 mutations |
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要素 | Protein disulfide-isomerase |
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キーワード | ISOMERASE / PDI |
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機能・相同性 | 機能・相同性情報
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / procollagen-proline 4-dioxygenase complex / VLDL assembly / insulin processing / interleukin-23-mediated signaling pathway / LDL remodeling / procollagen-proline 4-dioxygenase activity / thiol oxidase activity / protein disulfide-isomerase / peptidyl-proline hydroxylation to 4-hydroxy-L-proline ...regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / procollagen-proline 4-dioxygenase complex / VLDL assembly / insulin processing / interleukin-23-mediated signaling pathway / LDL remodeling / procollagen-proline 4-dioxygenase activity / thiol oxidase activity / protein disulfide-isomerase / peptidyl-proline hydroxylation to 4-hydroxy-L-proline / endoplasmic reticulum chaperone complex / Collagen biosynthesis and modifying enzymes / protein folding in endoplasmic reticulum / Chylomicron assembly / Interleukin-23 signaling / interleukin-12-mediated signaling pathway / cellular response to interleukin-7 / Interleukin-12 signaling / protein disulfide isomerase activity / Insulin processing / Detoxification of Reactive Oxygen Species / endoplasmic reticulum-Golgi intermediate compartment / positive regulation of cell adhesion / protein-disulfide reductase activity / endoplasmic reticulum to Golgi vesicle-mediated transport / positive regulation of substrate adhesion-dependent cell spreading / response to endoplasmic reticulum stress / Hedgehog ligand biogenesis / Post-translational protein phosphorylation / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / melanosome / integrin binding / protein folding / lamellipodium / actin binding / cellular response to hypoxia / positive regulation of viral entry into host cell / cytoskeleton / protein heterodimerization activity / endoplasmic reticulum lumen / external side of plasma membrane / focal adhesion / enzyme binding / endoplasmic reticulum / protein-containing complex / RNA binding / extracellular exosome / extracellular region / cytosol類似検索 - 分子機能 Protein disulphide isomerase / Thioredoxin-like domain / Disulphide isomerase / Endoplasmic reticulum targeting sequence. / Thioredoxin / Thioredoxin, conserved site / Thioredoxin family active site. / Thioredoxin domain profile. / Thioredoxin domain / Thioredoxin-like superfamily類似検索 - ドメイン・相同性 THIOCYANATE ION / Protein disulfide-isomerase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.05 Å |
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データ登録者 | Forouhar, F. / Banayan, N.E. / Loughlin, B.L. / Singh, S. / Wong, V. / Hunt, H.S. / Handelman, S.K. / Price, N. / Hunt, J.F. |
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資金援助 | 1件 |
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引用 | ジャーナル: Protein Sci. / 年: 2024 タイトル: Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution. 著者: Banayan, N.E. / Loughlin, B.J. / Singh, S. / Forouhar, F. / Lu, G. / Wong, K.H. / Neky, M. / Hunt, H.S. / Bateman Jr., L.B. / Tamez, A. / Handelman, S.K. / Price, W.N. / Hunt, J.F. |
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履歴 | 登録 | 2023年3月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2024年1月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年3月20日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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