登録情報 | データベース: PDB / ID: 8gdn |
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タイトル | Structure of PmHMGR bound to mevalonate, CoA and NAD. |
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要素 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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キーワード | STRUCTURAL PROTEIN / Non-Rossmann fold / Homodimer / Reductase / HMG-CoA |
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機能・相同性 | 機能・相同性情報
hydroxymethylglutaryl-CoA reductase (NADH) activity / hydroxymethylglutaryl-CoA reductase / hydroxymethylglutaryl-CoA reductase (NADPH) activity / coenzyme A metabolic process / ergosterol biosynthetic process / isoprenoid biosynthetic process / peroxisomal membrane類似検索 - 分子機能 Hydroxymethylglutaryl-CoA reductase, bacterial-type / Hydroxymethylglutaryl-coenzyme A reductases signature 2. / Hydroxymethylglutaryl-coenzyme A reductases signature 1. / Hydroxymethylglutaryl-coenzyme A reductases signature 3. / Hydroxymethylglutaryl-CoA reductase, class I/II / Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily / Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily / Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily / Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site / Hydroxymethylglutaryl-coenzyme A reductase / Hydroxymethylglutaryl-coenzyme A reductases family profile.類似検索 - ドメイン・相同性 COENZYME A / (R)-MEVALONATE / NICOTINAMIDE-ADENINE-DINUCLEOTIDE / 3-hydroxy-3-methylglutaryl-coenzyme A reductase類似検索 - 構成要素 |
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生物種 | Pseudomonas sp. 'mevalonii' (バクテリア) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.99 Å |
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データ登録者 | Purohit, V. / Steussy, C.N. / Stauffacher, C.V. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | RO1 GM111645 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | P30 CA023168 | 米国 |
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引用 | ジャーナル: Biophys.J. / 年: 2024 タイトル: pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography. 著者: Purohit, V. / Steussy, C.N. / Rosales, A.R. / Critchelow, C.J. / Schmidt, T. / Helquist, P. / Wiest, O. / Mesecar, A. / Cohen, A.E. / Stauffacher, C.V. |
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履歴 | 登録 | 2023年3月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2024年3月20日 | Provider: repository / タイプ: Initial release |
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