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- PDB-8fmg: Structure of CBASS Cap5 from Pseudomonas syringae as an activated... -

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基本情報

登録情報
データベース: PDB / ID: 8fmg
タイトルStructure of CBASS Cap5 from Pseudomonas syringae as an activated tetramer with the cyclic dinucleotide 3'2'-c-diAMP ligand (3 tetramers in the AU)
要素SAVED domain-containing protein
キーワードIMMUNE SYSTEM / cyclic dinucleotide / bacterial immunity / CBASS / Cap5 effector DNA endonuclease / viral defense
機能・相同性HNH endonuclease / SMODS-associated and fused to various effectors / SMODS-associated and fused to various effectors sensor domain / HNH nuclease / metal ion binding / : / HNH endonuclease
機能・相同性情報
生物種Pseudomonas syringae (バクテリア)
手法X線回折 / シンクロトロン / 分子置換 / 解像度: 1.79 Å
データ登録者Rechkoblit, O. / Kreitler, D.F. / Aggarwal, A.K.
資金援助 米国, 1件
組織認可番号国
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM13170 米国
引用ジャーナル: Nat.Struct.Mol.Biol. / 年: 2024
タイトル: Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides.
著者: Rechkoblit, O. / Sciaky, D. / Kreitler, D.F. / Buku, A. / Kottur, J. / Aggarwal, A.K.
履歴
登録2022年12月23日登録サイト: RCSB / 処理サイト: RCSB
改定 1.02024年2月7日Provider: repository / タイプ: Initial release
改定 1.12024年2月21日Group: Database references / カテゴリ: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title
改定 1.22024年5月29日Group: Database references / カテゴリ: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID

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構造の表示

構造ビューア分子:
MolmilJmol/JSmol

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集合体

登録構造単位
A: SAVED domain-containing protein
B: SAVED domain-containing protein
C: SAVED domain-containing protein
D: SAVED domain-containing protein
E: SAVED domain-containing protein
F: SAVED domain-containing protein
G: SAVED domain-containing protein
H: SAVED domain-containing protein
K: SAVED domain-containing protein
L: SAVED domain-containing protein
M: SAVED domain-containing protein
N: SAVED domain-containing protein
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)522,23349
ポリマ－513,23112
非ポリマー9,00237
水44,5692474
1
A: SAVED domain-containing protein
B: SAVED domain-containing protein
C: SAVED domain-containing protein
D: SAVED domain-containing protein
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)174,06916
ポリマ－171,0774
非ポリマー2,99312
水724
タイプ名称対称操作数
identity operation1_555x,y,z1
Buried area19120 Å2
ΔGint-93 kcal/mol
Surface area53050 Å2
手法PISA
2
E: SAVED domain-containing protein
F: SAVED domain-containing protein
G: SAVED domain-containing protein
H: SAVED domain-containing protein
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)174,09417
ポリマ－171,0774
非ポリマー3,01713
水724
タイプ名称対称操作数
identity operation1_555x,y,z1
Buried area18990 Å2
ΔGint-92 kcal/mol
Surface area53900 Å2
手法PISA
3
K: SAVED domain-containing protein
L: SAVED domain-containing protein
M: SAVED domain-containing protein
N: SAVED domain-containing protein
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)174,06916
ポリマ－171,0774
非ポリマー2,99312
水724
タイプ名称対称操作数
identity operation1_555x,y,z1
Buried area19190 Å2
ΔGint-100 kcal/mol
Surface area53990 Å2
手法PISA
単位格子
Length a, b, c (Å)145.192, 80.522, 406.841
Angle α, β, γ (deg.)90.000, 90.620, 90.000
Int Tables number5
Space group name H-MC121
Space group name HallC2y
Symmetry operation#1: x,y,z
#2: -x,y,-z
#3: x+1/2,y+1/2,z
#4: -x+1/2,y+1/2,-z
Components on special symmetry positions
IDモデル要素
11A-630-

HOH

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要素

#1: タンパク質
SAVED domain-containing protein / CBASS Cap5


分子量: 42769.238 Da / 分子数: 12 / 由来タイプ: 組換発現
由来: (組換発現) Pseudomonas syringae (バクテリア)
発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: A0A2P0QGK5
#2: 化合物
ChemComp-ZN / ZINC ION


分子量: 65.409 Da / 分子数: 12 / 由来タイプ: 合成 / 式: Zn
#3: 化合物
ChemComp-MG / MAGNESIUM ION / マグネシウムジカチオン


分子量: 24.305 Da / 分子数: 13 / 由来タイプ: 合成 / 式: Mg
#4: 化合物
ChemComp-Y4F / Cyclic (adenosine-(2'-5')-monophosphate-adenosine-(3'-5')-monophosphate


分子量: 658.412 Da / 分子数: 12 / 由来タイプ: 合成 / 式: C20H24N10O12P2 / タイプ: SUBJECT OF INVESTIGATION
#5: 水 ChemComp-HOH / water


分子量: 18.015 Da / 分子数: 2474 / 由来タイプ: 天然 / 式: H2O
研究の焦点であるリガンドがあるかY

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実験情報

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実験

実験手法: X線回折 / 使用した結晶の数: 1

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試料調製

結晶マシュー密度: 2.32 Å3/Da / 溶媒含有率: 46.91 %
結晶化温度: 293 K / 手法: 蒸気拡散法, ハンギングドロップ法
詳細: 0.1 M Bis-Tris, pH 5.5-6.0, 0.2 M magnesium chloride, 19-20% PEG3350
PH範囲: 5.5-6.0

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データ収集

回折平均測定温度: 100 K / Serial crystal experiment: N
放射光源由来: シンクロトロン / サイト: NSLS-II / ビームライン: 17-ID-1 / 波長: 0.920105 Å
検出器タイプ: DECTRIS EIGER2 S 9M / 検出器: PIXEL / 日付: 2022年3月17日
放射プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長波長: 0.920105 Å / 相対比: 1
反射解像度: 1.79→203.4 Å / Num. obs: 267508 / % possible obs: 88.7 % / 冗長度: 2.1 % / Biso Wilson estimate: 26.98 Å2 / CC1/2: 0.997 / Rmerge(I) obs: 0.071 / Net I/σ(I): 7
反射 シェル解像度: 1.79→2.001 Å / Rmerge(I) obs: 0.645 / Num. unique obs: 13376 / CC1/2: 0.58

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解析

ソフトウェア
名称バージョン分類
PHENIX1.20.1_4487精密化
PHENIX1.20.1_4487精密化
XDSデータ削減
Aimlessデータスケーリング
PHENIX位相決定
精密化構造決定の手法: 分子置換
開始モデル: PDB entry 8FMF

8fmf


解像度: 1.79→58.12 Å / SU ML: 0.2254 / 交差検証法: FREE R-VALUE / σ(F): 1.36 / 位相誤差: 28.6414
立体化学のターゲット値: GeoStd + Monomer Library + CDL v1.2
Rfactor反射数%反射
Rfree0.2254 12884 4.82 %
Rwork0.1794 254562 -
obs0.1816 267446 61 %
溶媒の処理減衰半径: 0.9 Å / VDWプローブ半径: 1.1 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL
原子変位パラメータBiso mean: 33.78 Å2
精密化ステップサイクル: LAST / 解像度: 1.79→58.12 Å
タンパク質核酸リガンド溶媒全体
原子数33404 0 553 2481 36438
拘束条件
Refine-IDタイプDev ideal数
X-RAY DIFFRACTIONf_bond_d0.003734901
X-RAY DIFFRACTIONf_angle_d0.699847727
X-RAY DIFFRACTIONf_chiral_restr0.04375355
X-RAY DIFFRACTIONf_plane_restr0.00676292
X-RAY DIFFRACTIONf_dihedral_angle_d14.082213076
LS精密化 シェル
解像度 (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
1.79-1.810.209220.300419X-RAY DIFFRACTION0.15
1.81-1.840.477560.301593X-RAY DIFFRACTION0.69
1.84-1.860.4495180.2944362X-RAY DIFFRACTION2.62
1.86-1.880.3883470.2968957X-RAY DIFFRACTION6.9
1.88-1.910.3219870.28441647X-RAY DIFFRACTION11.99
1.91-1.930.32281080.28172106X-RAY DIFFRACTION15.11
1.93-1.960.28871320.27082751X-RAY DIFFRACTION19.91
1.96-1.990.26461630.26693410X-RAY DIFFRACTION24.59
1.99-2.020.28892140.25964131X-RAY DIFFRACTION29.63
2.02-2.050.29962340.25554884X-RAY DIFFRACTION35.54
2.05-2.090.27183120.24885545X-RAY DIFFRACTION40.16
2.09-2.130.28653460.24276574X-RAY DIFFRACTION47.1
2.13-2.170.27893510.23957816X-RAY DIFFRACTION56.18
2.17-2.210.28984560.23849083X-RAY DIFFRACTION65.84
2.21-2.260.25715170.224810216X-RAY DIFFRACTION73.74
2.26-2.310.26786250.21911149X-RAY DIFFRACTION80.26
2.31-2.370.26465930.218411896X-RAY DIFFRACTION85.41
2.37-2.430.26586330.21712406X-RAY DIFFRACTION89.3
2.43-2.510.27356220.218912964X-RAY DIFFRACTION93.3
2.51-2.590.27336600.212913156X-RAY DIFFRACTION94.68
2.59-2.680.25646930.213813416X-RAY DIFFRACTION96.48
2.68-2.790.23777100.211113533X-RAY DIFFRACTION97.84
2.79-2.910.24426230.19413553X-RAY DIFFRACTION97.28
2.91-3.070.2347660.186913513X-RAY DIFFRACTION96.89
3.07-3.260.22717030.185513273X-RAY DIFFRACTION95.89
3.26-3.510.21716810.169813275X-RAY DIFFRACTION94.76
3.51-3.860.20565790.146213164X-RAY DIFFRACTION93.75
3.86-4.420.16895850.119213184X-RAY DIFFRACTION93.01
4.42-5.570.16987040.122712966X-RAY DIFFRACTION92.41
5.57-58.120.20987140.176713520X-RAY DIFFRACTION94.13
精密化 TLS手法: refined / Origin x: -48.63 Å / Origin y: 7.28 Å / Origin z: 101.641 Å
111213212223313233
T0.118670935025 Å2-0.0117975449535 Å20.00134006064255 Å2-0.0910129619152 Å20.0246946388126 Å2--0.135745870849 Å2
L0.0291120258197 °2-0.00395021859199 °20.0133408879988 °2--0.00904573423075 °2-0.0213484280998 °2--0.132729698485 °2
S-0.00469347289059 Å °0.0196815881505 Å °0.0023715179425 Å °0.0148392868881 Å °0.00473998184826 Å °0.0055519305014 Å °-0.0388016094409 Å °0.0135689577156 Å °-0.001317619217 Å °
精密化 TLSグループ
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )A14 - 382
2X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )A401
3X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )A402 - 403
4X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )A404
5X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )A501 - 730
6X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )B13 - 382
7X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )B401
8X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )B402
9X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )B501 - 718
10X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )C15 - 382
11X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )C401
12X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )C402 - 403
13X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )C404
14X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )C501 - 706
15X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )D14 - 382
16X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )D401
17X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )D402
18X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )D501 - 641
19X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )E14 - 382
20X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )E401
21X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )E402 - 403
22X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )E404
23X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )E501 - 752
24X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )F14 - 382
25X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )F401
26X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )F402
27X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )F501 - 662
28X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )G15 - 382
29X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )G401
30X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )G402 - 403
31X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )G404
32X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )G501 - 732
33X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )H11 - 382
34X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )H401
35X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )H402
36X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )H403
37X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )H501 - 712
38X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )K14 - 382
39X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )K401
40X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )K402 - 403
41X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )K404
42X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )K501 - 733
43X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )L12 - 382
44X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )L401
45X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )L402
46X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )L501 - 723
47X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )M14 - 382
48X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )M401
49X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )M402 - 403
50X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )M404
51X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )M501 - 702
52X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )N13 - 382
53X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )N401
54X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )N402
55X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )N501 - 663

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

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