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- PDB-8fmg: Structure of CBASS Cap5 from Pseudomonas syringae as an activated... -

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Basic information

Entry
Database: PDB / ID: 8fmg
TitleStructure of CBASS Cap5 from Pseudomonas syringae as an activated tetramer with the cyclic dinucleotide 3'2'-c-diAMP ligand (3 tetramers in the AU)
ComponentsSAVED domain-containing protein
KeywordsIMMUNE SYSTEM / cyclic dinucleotide / bacterial immunity / CBASS / Cap5 effector DNA endonuclease / viral defense
Function / homologyHNH endonuclease / SMODS-associated and fused to various effectors / SMODS-associated and fused to various effectors sensor domain / HNH nuclease / metal ion binding / : / HNH endonuclease
Function and homology information
Biological speciesPseudomonas syringae (bacteria)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.79 Å
AuthorsRechkoblit, O. / Kreitler, D.F. / Aggarwal, A.K.
Funding support United States, 1items
OrganizationGrant numberCountry
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM13170 United States
CitationJournal: Nat.Struct.Mol.Biol. / Year: 2024
Title: Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides.
Authors: Rechkoblit, O. / Sciaky, D. / Kreitler, D.F. / Buku, A. / Kottur, J. / Aggarwal, A.K.
History
DepositionDec 23, 2022Deposition site: RCSB / Processing site: RCSB
Revision 1.0Feb 7, 2024Provider: repository / Type: Initial release
Revision 1.1Feb 21, 2024Group: Database references / Category: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title
Revision 1.2May 29, 2024Group: Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: SAVED domain-containing protein
B: SAVED domain-containing protein
C: SAVED domain-containing protein
D: SAVED domain-containing protein
E: SAVED domain-containing protein
F: SAVED domain-containing protein
G: SAVED domain-containing protein
H: SAVED domain-containing protein
K: SAVED domain-containing protein
L: SAVED domain-containing protein
M: SAVED domain-containing protein
N: SAVED domain-containing protein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)522,23349
Polymers513,23112
Non-polymers9,00237
Water44,5692474
1
A: SAVED domain-containing protein
B: SAVED domain-containing protein
C: SAVED domain-containing protein
D: SAVED domain-containing protein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)174,06916
Polymers171,0774
Non-polymers2,99312
Water724
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area19120 Å2
ΔGint-93 kcal/mol
Surface area53050 Å2
MethodPISA
2
E: SAVED domain-containing protein
F: SAVED domain-containing protein
G: SAVED domain-containing protein
H: SAVED domain-containing protein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)174,09417
Polymers171,0774
Non-polymers3,01713
Water724
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area18990 Å2
ΔGint-92 kcal/mol
Surface area53900 Å2
MethodPISA
3
K: SAVED domain-containing protein
L: SAVED domain-containing protein
M: SAVED domain-containing protein
N: SAVED domain-containing protein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)174,06916
Polymers171,0774
Non-polymers2,99312
Water724
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area19190 Å2
ΔGint-100 kcal/mol
Surface area53990 Å2
MethodPISA
Unit cell
Length a, b, c (Å)145.192, 80.522, 406.841
Angle α, β, γ (deg.)90.000, 90.620, 90.000
Int Tables number5
Space group name H-MC121
Space group name HallC2y
Symmetry operation#1: x,y,z
#2: -x,y,-z
#3: x+1/2,y+1/2,z
#4: -x+1/2,y+1/2,-z
Components on special symmetry positions
IDModelComponents
11A-630-

HOH

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Components

#1: Protein
SAVED domain-containing protein / CBASS Cap5


Mass: 42769.238 Da / Num. of mol.: 12
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Pseudomonas syringae (bacteria) / Production host: Escherichia coli (E. coli) / References: UniProt: A0A2P0QGK5
#2: Chemical
ChemComp-ZN / ZINC ION


Mass: 65.409 Da / Num. of mol.: 12 / Source method: obtained synthetically / Formula: Zn
#3: Chemical
ChemComp-MG / MAGNESIUM ION


Mass: 24.305 Da / Num. of mol.: 13 / Source method: obtained synthetically / Formula: Mg
#4: Chemical
ChemComp-Y4F / Cyclic (adenosine-(2'-5')-monophosphate-adenosine-(3'-5')-monophosphate


Mass: 658.412 Da / Num. of mol.: 12 / Source method: obtained synthetically / Formula: C20H24N10O12P2 / Feature type: SUBJECT OF INVESTIGATION
#5: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 2474 / Source method: isolated from a natural source / Formula: H2O
Has ligand of interestY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.32 Å3/Da / Density % sol: 46.91 %
Crystal growTemperature: 293 K / Method: vapor diffusion, hanging drop
Details: 0.1 M Bis-Tris, pH 5.5-6.0, 0.2 M magnesium chloride, 19-20% PEG3350
PH range: 5.5-6.0

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: NSLS-II / Beamline: 17-ID-1 / Wavelength: 0.920105 Å
DetectorType: DECTRIS EIGER2 S 9M / Detector: PIXEL / Date: Mar 17, 2022
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.920105 Å / Relative weight: 1
ReflectionResolution: 1.79→203.4 Å / Num. obs: 267508 / % possible obs: 88.7 % / Redundancy: 2.1 % / Biso Wilson estimate: 26.98 Å2 / CC1/2: 0.997 / Rmerge(I) obs: 0.071 / Net I/σ(I): 7
Reflection shellResolution: 1.79→2.001 Å / Rmerge(I) obs: 0.645 / Num. unique obs: 13376 / CC1/2: 0.58

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Processing

Software
NameVersionClassification
PHENIX1.20.1_4487refinement
PHENIX1.20.1_4487refinement
XDSdata reduction
Aimlessdata scaling
PHENIXphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: PDB entry 8FMF

8fmf


Resolution: 1.79→58.12 Å / SU ML: 0.2254 / Cross valid method: FREE R-VALUE / σ(F): 1.36 / Phase error: 28.6414
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2254 12884 4.82 %
Rwork0.1794 254562 -
obs0.1816 267446 61 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 33.78 Å2
Refinement stepCycle: LAST / Resolution: 1.79→58.12 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms33404 0 553 2481 36438
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.003734901
X-RAY DIFFRACTIONf_angle_d0.699847727
X-RAY DIFFRACTIONf_chiral_restr0.04375355
X-RAY DIFFRACTIONf_plane_restr0.00676292
X-RAY DIFFRACTIONf_dihedral_angle_d14.082213076
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
1.79-1.810.209220.300419X-RAY DIFFRACTION0.15
1.81-1.840.477560.301593X-RAY DIFFRACTION0.69
1.84-1.860.4495180.2944362X-RAY DIFFRACTION2.62
1.86-1.880.3883470.2968957X-RAY DIFFRACTION6.9
1.88-1.910.3219870.28441647X-RAY DIFFRACTION11.99
1.91-1.930.32281080.28172106X-RAY DIFFRACTION15.11
1.93-1.960.28871320.27082751X-RAY DIFFRACTION19.91
1.96-1.990.26461630.26693410X-RAY DIFFRACTION24.59
1.99-2.020.28892140.25964131X-RAY DIFFRACTION29.63
2.02-2.050.29962340.25554884X-RAY DIFFRACTION35.54
2.05-2.090.27183120.24885545X-RAY DIFFRACTION40.16
2.09-2.130.28653460.24276574X-RAY DIFFRACTION47.1
2.13-2.170.27893510.23957816X-RAY DIFFRACTION56.18
2.17-2.210.28984560.23849083X-RAY DIFFRACTION65.84
2.21-2.260.25715170.224810216X-RAY DIFFRACTION73.74
2.26-2.310.26786250.21911149X-RAY DIFFRACTION80.26
2.31-2.370.26465930.218411896X-RAY DIFFRACTION85.41
2.37-2.430.26586330.21712406X-RAY DIFFRACTION89.3
2.43-2.510.27356220.218912964X-RAY DIFFRACTION93.3
2.51-2.590.27336600.212913156X-RAY DIFFRACTION94.68
2.59-2.680.25646930.213813416X-RAY DIFFRACTION96.48
2.68-2.790.23777100.211113533X-RAY DIFFRACTION97.84
2.79-2.910.24426230.19413553X-RAY DIFFRACTION97.28
2.91-3.070.2347660.186913513X-RAY DIFFRACTION96.89
3.07-3.260.22717030.185513273X-RAY DIFFRACTION95.89
3.26-3.510.21716810.169813275X-RAY DIFFRACTION94.76
3.51-3.860.20565790.146213164X-RAY DIFFRACTION93.75
3.86-4.420.16895850.119213184X-RAY DIFFRACTION93.01
4.42-5.570.16987040.122712966X-RAY DIFFRACTION92.41
5.57-58.120.20987140.176713520X-RAY DIFFRACTION94.13
Refinement TLS params.Method: refined / Origin x: -48.63 Å / Origin y: 7.28 Å / Origin z: 101.641 Å
111213212223313233
T0.118670935025 Å2-0.0117975449535 Å20.00134006064255 Å2-0.0910129619152 Å20.0246946388126 Å2--0.135745870849 Å2
L0.0291120258197 °2-0.00395021859199 °20.0133408879988 °2--0.00904573423075 °2-0.0213484280998 °2--0.132729698485 °2
S-0.00469347289059 Å °0.0196815881505 Å °0.0023715179425 Å °0.0148392868881 Å °0.00473998184826 Å °0.0055519305014 Å °-0.0388016094409 Å °0.0135689577156 Å °-0.001317619217 Å °
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )A14 - 382
2X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )A401
3X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )A402 - 403
4X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )A404
5X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )A501 - 730
6X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )B13 - 382
7X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )B401
8X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )B402
9X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )B501 - 718
10X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )C15 - 382
11X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )C401
12X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )C402 - 403
13X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )C404
14X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )C501 - 706
15X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )D14 - 382
16X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )D401
17X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )D402
18X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )D501 - 641
19X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )E14 - 382
20X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )E401
21X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )E402 - 403
22X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )E404
23X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )E501 - 752
24X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )F14 - 382
25X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )F401
26X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )F402
27X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )F501 - 662
28X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )G15 - 382
29X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )G401
30X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )G402 - 403
31X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )G404
32X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )G501 - 732
33X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )H11 - 382
34X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )H401
35X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )H402
36X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )H403
37X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )H501 - 712
38X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )K14 - 382
39X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )K401
40X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )K402 - 403
41X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )K404
42X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )K501 - 733
43X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )L12 - 382
44X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )L401
45X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )L402
46X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )L501 - 723
47X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )M14 - 382
48X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )M401
49X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )M402 - 403
50X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )M404
51X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )M501 - 702
52X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )N13 - 382
53X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )N401
54X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )N402
55X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:730 ) ) OR ( CHAIN B AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:718 ) ) OR ( CHAIN C AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:706 ) ) OR ( CHAIN D AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:641 ) ) OR ( CHAIN E AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:752 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:662 ) ) OR ( CHAIN G AND ( RESID 15:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:732 ) ) OR ( CHAIN H AND ( RESID 11:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:712 ) ) OR ( CHAIN K AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:733 ) ) OR ( CHAIN L AND ( RESID 12:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:723 ) ) OR ( CHAIN M AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:403 OR RESID 404:404 OR RESID 501:702 ) ) OR ( CHAIN N AND ( RESID 13:382 OR RESID 401:401 OR RESID 402:402 OR RESID 501:663 ) )N501 - 663

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