+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 8f5y | ||||||
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タイトル | Crystal structure of pregnane X receptor ligand binding domain complexed with JQ1 | ||||||
要素 |
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キーワード | TRANSCRIPTION (転写 (生物学)) / nuclear receptor (核内受容体) / transcription factor (転写因子) / metabolism (代謝) / antibiotic (抗生物質) | ||||||
機能・相同性 | 機能・相同性情報 xenobiotic transport / labyrinthine layer morphogenesis / regulation of thyroid hormone mediated signaling pathway / positive regulation of transcription from RNA polymerase II promoter by galactose / positive regulation of female receptivity / intermediate filament cytoskeleton / hypothalamus development / male mating behavior / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / steroid metabolic process ...xenobiotic transport / labyrinthine layer morphogenesis / regulation of thyroid hormone mediated signaling pathway / positive regulation of transcription from RNA polymerase II promoter by galactose / positive regulation of female receptivity / intermediate filament cytoskeleton / hypothalamus development / male mating behavior / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / steroid metabolic process / cellular response to Thyroglobulin triiodothyronine / estrous cycle / Synthesis of bile acids and bile salts / Endogenous sterols / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / xenobiotic catabolic process / nuclear retinoid X receptor binding / response to retinoic acid / histone acetyltransferase activity / regulation of cellular response to insulin stimulus / Recycling of bile acids and salts / ヒストンアセチルトランスフェラーゼ / cellular response to hormone stimulus / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / positive regulation of adipose tissue development / peroxisome proliferator activated receptor signaling pathway / RORA activates gene expression / 授乳 / positive regulation of neuron differentiation / Regulation of lipid metabolism by PPARalpha / xenobiotic metabolic process / cerebellum development / BMAL1:CLOCK,NPAS2 activates circadian gene expression / SUMOylation of transcription cofactors / Activation of gene expression by SREBF (SREBP) / nuclear receptor coactivator activity / response to progesterone / nuclear estrogen receptor binding / hippocampus development / nuclear receptor binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Heme signaling / SUMOylation of intracellular receptors / mRNA transcription by RNA polymerase II / Transcriptional activation of mitochondrial biogenesis / PPARA activates gene expression / Cytoprotection by HMOX1 / cerebral cortex development / Transcriptional regulation of white adipocyte differentiation / Nuclear Receptor transcription pathway / RNA polymerase II transcription regulator complex / nuclear receptor activity / male gonad development / sequence-specific double-stranded DNA binding / Circadian Clock / response to estradiol / HATs acetylate histones / DNA-binding transcription activator activity, RNA polymerase II-specific / Estrogen-dependent gene expression / transcription regulator complex / transcription coactivator activity / 細胞分化 / nuclear body / protein dimerization activity / DNA-binding transcription factor activity, RNA polymerase II-specific / positive regulation of apoptotic process / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of DNA-templated transcription / chromatin binding / クロマチン / regulation of DNA-templated transcription / positive regulation of gene expression / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / シグナル伝達 / positive regulation of transcription by RNA polymerase II / protein-containing complex / zinc ion binding / 核質 / 細胞核 / 細胞膜 / 細胞質基質 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.15 Å | ||||||
データ登録者 | Huber, A.D. / Poudel, S. / Seetharaman, J. / Miller, D.J. / Chen, T. | ||||||
資金援助 | 米国, 1件
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引用 | ジャーナル: Nucleic Acids Res. / 年: 2024 タイトル: A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR. 著者: Huber, A.D. / Poudel, S. / Wu, J. / Miller, D.J. / Lin, W. / Yang, L. / Bwayi, M.N. / Rimmer, M.A. / Gee, R.R.F. / Seetharaman, J. / Chai, S.C. / Chen, T. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 8f5y.cif.gz | 131.7 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb8f5y.ent.gz | 97.4 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 8f5y.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/f5/8f5y ftp://data.pdbj.org/pub/pdb/validation_reports/f5/8f5y | HTTPS FTP |
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-関連構造データ
関連構造データ | 1nrlS S: 精密化の開始モデル |
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類似構造データ | 類似検索 - 機能・相同性F&H 検索 |
-リンク
-集合体
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非結晶学的対称性 (NCS) | NCSドメイン:
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