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- PDB-8f4v: Alpha7 nicotinic acetylcholine receptor intracellular and transme... -
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Open data
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Basic information
Entry | Database: PDB / ID: 8f4v | ||||||||||||
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Title | Alpha7 nicotinic acetylcholine receptor intracellular and transmembrane domains bound to ivermectin in a desensitized state | ||||||||||||
![]() | Neuronal acetylcholine receptor subunit alpha-7 | ||||||||||||
![]() | MEMBRANE PROTEIN / nicotinic acetylcholine receptor / transmembrane and intracellular domain / desensitized state / ivermectin | ||||||||||||
Function / homology | ![]() sensory processing / dendrite arborization / response to acetylcholine / Highly calcium permeable postsynaptic nicotinic acetylcholine receptors / acetylcholine-gated channel complex / regulation of amyloid fibril formation / short-term memory / positive regulation of CoA-transferase activity / acetylcholine receptor activity / dendritic spine organization ...sensory processing / dendrite arborization / response to acetylcholine / Highly calcium permeable postsynaptic nicotinic acetylcholine receptors / acetylcholine-gated channel complex / regulation of amyloid fibril formation / short-term memory / positive regulation of CoA-transferase activity / acetylcholine receptor activity / dendritic spine organization / acetylcholine binding / chloride channel regulator activity / regulation of amyloid precursor protein catabolic process / acetylcholine receptor signaling pathway / acetylcholine-gated monoatomic cation-selective channel activity / positive regulation of amyloid-beta formation / negative regulation of amyloid-beta formation / plasma membrane raft / modulation of excitatory postsynaptic potential / positive regulation of excitatory postsynaptic potential / response to amyloid-beta / negative regulation of tumor necrosis factor production / toxic substance binding / monoatomic ion transport / monoatomic ion transmembrane transport / positive regulation of protein metabolic process / positive regulation of long-term synaptic potentiation / synapse organization / response to nicotine / calcium channel activity / memory / cognition / intracellular calcium ion homeostasis / positive regulation of angiogenesis / calcium ion transport / monoatomic ion channel activity / amyloid-beta binding / postsynapse / postsynaptic membrane / positive regulation of MAPK cascade / learning or memory / positive regulation of ERK1 and ERK2 cascade / response to hypoxia / neuron projection / positive regulation of protein phosphorylation / synapse / positive regulation of cell population proliferation / signal transduction / protein homodimerization activity / membrane / plasma membrane Similarity search - Function | ||||||||||||
Biological species | ![]() | ||||||||||||
Method | SOLUTION NMR / na | ||||||||||||
![]() | Bondarenko, V. / Chen, Q. / Tang, P. | ||||||||||||
Funding support | ![]()
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![]() | ![]() Title: Structural Elucidation of Ivermectin Binding to alpha 7nAChR and the Induced Channel Desensitization. Authors: Bondarenko, V. / Chen, Q. / Singewald, K. / Haloi, N. / Tillman, T.S. / Howard, R.J. / Lindahl, E. / Xu, Y. / Tang, P. | ||||||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 5.9 MB | Display | ![]() |
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PDB format | ![]() | 5 MB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 758.9 KB | Display | ![]() |
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Full document | ![]() | 985.2 KB | Display | |
Data in XML | ![]() | 415.7 KB | Display | |
Data in CIF | ![]() | 504.4 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data | Similarity search - Function & homology ![]() |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein | Mass: 29831.779 Da / Num. of mol.: 5 Fragment: Transmembrane domain and intracellular domain residues 231-496 Mutation: A263S, V268S, L270S, A474E Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #2: Chemical | ChemComp-IVM / ( Has ligand of interest | Y | |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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Sample preparation
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