登録情報 | データベース: PDB / ID: 8dyf |
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タイトル | IL17A homodimer bound to Compound 10 |
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要素 | Interleukin-17A |
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キーワード | CYTOKINE / dimer / fragment / inhibitor / antagonist |
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機能・相同性 | 機能・相同性情報
positive regulation of interleukin-16 production / granulocyte migration / positive regulation of antimicrobial peptide production / Interleukin-17 signaling / intestinal epithelial structure maintenance / negative regulation of inflammatory response to wounding / interleukin-17A-mediated signaling pathway / positive regulation of interleukin-23 production / cell death / positive regulation of chemokine (C-X-C motif) ligand 1 production ...positive regulation of interleukin-16 production / granulocyte migration / positive regulation of antimicrobial peptide production / Interleukin-17 signaling / intestinal epithelial structure maintenance / negative regulation of inflammatory response to wounding / interleukin-17A-mediated signaling pathway / positive regulation of interleukin-23 production / cell death / positive regulation of chemokine (C-X-C motif) ligand 1 production / interleukin-17-mediated signaling pathway / positive regulation of bicellular tight junction assembly / fibroblast activation / positive regulation of cytokine production involved in inflammatory response / positive regulation of osteoclast differentiation / keratinocyte proliferation / cellular response to interleukin-1 / defense response to fungus / keratinocyte differentiation / Notch signaling pathway / positive regulation of interleukin-12 production / positive regulation of interleukin-1 beta production / cytokine activity / response to wounding / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / cell-cell signaling / gene expression / Interleukin-4 and Interleukin-13 signaling / defense response to Gram-negative bacterium / adaptive immune response / defense response to Gram-positive bacterium / inflammatory response / immune response / protein heterodimerization activity / external side of plasma membrane / innate immune response / apoptotic process / SARS-CoV-2 activates/modulates innate and adaptive immune responses / positive regulation of transcription by RNA polymerase II / protein homodimerization activity / extracellular space / extracellular region類似検索 - 分子機能 Interleukin-17, chordata / Interleukin-17 family / Interleukin-17 / Cystine-knot cytokine類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.02 Å |
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データ登録者 | Argiriadi, M.A. / Goedken, E.R. |
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資金援助 | 1件 |
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引用 | ジャーナル: Sci Rep / 年: 2022 タイトル: Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. 著者: Goedken, E.R. / Argiriadi, M.A. / Dietrich, J.D. / Petros, A.M. / Krishnan, N. / Panchal, S.C. / Qiu, W. / Wu, H. / Zhu, H. / Adams, A.M. / Bodelle, P.M. / Goguen, L. / Richardson, P.L. / ...著者: Goedken, E.R. / Argiriadi, M.A. / Dietrich, J.D. / Petros, A.M. / Krishnan, N. / Panchal, S.C. / Qiu, W. / Wu, H. / Zhu, H. / Adams, A.M. / Bodelle, P.M. / Goguen, L. / Richardson, P.L. / Slivka, P.F. / Srikumaran, M. / Upadhyay, A.K. / Wu, B. / Judge, R.A. / Vasudevan, A. / Gopalakrishnan, S.M. / Cox, P.B. / Stoll, V.S. / Sun, C. |
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履歴 | 登録 | 2022年8月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年9月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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