登録情報 | データベース: PDB / ID: 8dt7 |
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タイトル | X-ray structure of human acetylcholinesterase in complex with oxime MMB4 (hAChE-MMB4) |
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要素 | Acetylcholinesterase |
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キーワード | HYDROLASE / acetylcholine hydrolysis / oxime reactivator |
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機能・相同性 | 機能・相同性情報
negative regulation of synaptic transmission, cholinergic / serine hydrolase activity / Neurotransmitter clearance / acetylcholine catabolic process in synaptic cleft / cholinesterase activity / acetylcholine catabolic process / acetylcholinesterase / amyloid precursor protein metabolic process / acetylcholine binding / acetylcholine receptor signaling pathway ...negative regulation of synaptic transmission, cholinergic / serine hydrolase activity / Neurotransmitter clearance / acetylcholine catabolic process in synaptic cleft / cholinesterase activity / acetylcholine catabolic process / acetylcholinesterase / amyloid precursor protein metabolic process / acetylcholine binding / acetylcholine receptor signaling pathway / osteoblast development / acetylcholinesterase activity / Synthesis of PC / basement membrane / regulation of receptor recycling / Synthesis, secretion, and deacylation of Ghrelin / synaptic cleft / synapse assembly / side of membrane / laminin binding / collagen binding / positive regulation of protein secretion / neuromuscular junction / receptor internalization / amyloid-beta binding / positive regulation of cold-induced thermogenesis / nervous system development / retina development in camera-type eye / hydrolase activity / cell adhesion / synapse / perinuclear region of cytoplasm / Golgi apparatus / cell surface / protein homodimerization activity / extracellular space / extracellular region / nucleus / membrane / plasma membrane類似検索 - 分子機能 Acetylcholinesterase, tetramerisation domain / Acetylcholinesterase tetramerisation domain / : / Cholinesterase / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase type B, active site / Carboxylesterases type-B serine active site. / Carboxylesterase, type B / Carboxylesterase family ...Acetylcholinesterase, tetramerisation domain / Acetylcholinesterase tetramerisation domain / : / Cholinesterase / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase type B, active site / Carboxylesterases type-B serine active site. / Carboxylesterase, type B / Carboxylesterase family / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Chem-3VI / NITRATE ION / Acetylcholinesterase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.207 Å |
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データ登録者 | Kovalevsky, A.Y. / Gerlits, O. / Radic, Z. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | U01NS083451 | 米国 |
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引用 | ジャーナル: Structure / 年: 2022 タイトル: Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering. 著者: Gerlits, O. / Fajer, M. / Cheng, X. / Blumenthal, D.K. / Radic, Z. / Kovalevsky, A. |
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履歴 | 登録 | 2022年7月25日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年11月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年11月16日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.2 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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改定 1.3 | 2024年11月6日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature Item: _pdbx_entry_details.has_protein_modification |
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