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- PDB-8ddc: Intramembrane recognition between transmembrane domains of IL-7R ... -
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Open data
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Basic information
Entry | Database: PDB / ID: 8ddc | ||||||||||||
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Title | Intramembrane recognition between transmembrane domains of IL-7R and common gamma chain | ||||||||||||
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![]() | MEMBRANE PROTEIN / common gamma-chain cytokine receptor / transmembrane domain / receptor sharing | ||||||||||||
Function / homology | ![]() Interleukin-2 signaling / Interleukin-21 signaling / Interleukin-9 signaling / Interleukin-4 and Interleukin-13 signaling / mature B cell differentiation / Interleukin-15 signaling / interleukin-15 receptor activity / interleukin-2 binding / CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / Interleukin-7 signaling ...Interleukin-2 signaling / Interleukin-21 signaling / Interleukin-9 signaling / Interleukin-4 and Interleukin-13 signaling / mature B cell differentiation / Interleukin-15 signaling / interleukin-15 receptor activity / interleukin-2 binding / CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / Interleukin-7 signaling / negative regulation of T cell mediated cytotoxicity / RAF/MAP kinase cascade / Interleukin receptor SHC signaling / positive regulation of T cell differentiation in thymus / lymphocyte differentiation / interleukin-9-mediated signaling pathway / Cargo recognition for clathrin-mediated endocytosis / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / interleukin-2-mediated signaling pathway / Clathrin-mediated endocytosis / negative regulation of T cell apoptotic process / interleukin-15-mediated signaling pathway / cytokine receptor activity / positive regulation of B cell differentiation / regulation of cell size / cytokine binding / B cell proliferation / T cell homeostasis / B cell homeostasis / hemopoiesis / T cell differentiation / lymph node development / coreceptor activity / positive regulation of phagocytosis / B cell differentiation / positive regulation of receptor signaling pathway via JAK-STAT / cell morphogenesis / T cell mediated cytotoxicity / cytokine-mediated signaling pathway / gene expression / T cell differentiation in thymus / regulation of gene expression / receptor complex / defense response to Gram-positive bacterium / external side of plasma membrane / positive regulation of cell population proliferation / positive regulation of gene expression / cell surface / endoplasmic reticulum / nucleoplasm / plasma membrane / cytosol Similarity search - Function | ||||||||||||
Biological species | ![]() ![]() | ||||||||||||
Method | SOLUTION NMR / simulated annealing | ||||||||||||
![]() | Cai, T. / Lenoir Capello, R. / Chou, J.J. | ||||||||||||
Funding support | ![]()
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![]() | ![]() Title: Structural basis of gamma chain family receptor sharing at the membrane level. Authors: Cai, T. / Lenoir Capello, R. / Pi, X. / Wu, H. / Chou, J.J. | ||||||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 318.8 KB | Display | ![]() |
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PDB format | ![]() | 269.2 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 550.7 KB | Display | ![]() |
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Full document | ![]() | 810.4 KB | Display | |
Data in XML | ![]() | 27.7 KB | Display | |
Data in CIF | ![]() | 40 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 8dddC C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein/peptide | Mass: 3864.547 Da / Num. of mol.: 1 / Fragment: Transmembrane domain, residues 253-286 / Mutation: M271V, C282F Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() |
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#2: Protein/peptide | Mass: 3452.199 Da / Num. of mol.: 1 / Fragment: Transmembrane domain, residues 236-266 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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Sample preparation
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