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Open data
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Basic information
Entry | Database: PDB / ID: 8cjt | ||||||
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Title | JzTx-34 toxin peptide W33A mutant | ||||||
![]() | Mu-theraphotoxin-Cg1a | ||||||
![]() | TOXIN / JZTX-34 PEPTIDE TOXIN / hNav1.1 channel sodium channel | ||||||
Function / homology | Huwentoxin-1 family / Ion channel inhibitory toxin / ion channel inhibitor activity / potassium channel regulator activity / sodium channel regulator activity / toxin activity / extracellular region / Mu-theraphotoxin-Cg1a![]() | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR / molecular dynamics | ||||||
![]() | Landon, C. / Meudal, H. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Structure-function relationship of new peptides activating human Na v 1.1. Authors: Lopez, L. / De Waard, S. / Meudal, H. / Caumes, C. / Khakh, K. / Peigneur, S. / Oliveira-Mendes, B. / Lin, S. / De Waele, J. / Montnach, J. / Cestele, S. / Tessier, A. / Johnson, J.P. / ...Authors: Lopez, L. / De Waard, S. / Meudal, H. / Caumes, C. / Khakh, K. / Peigneur, S. / Oliveira-Mendes, B. / Lin, S. / De Waele, J. / Montnach, J. / Cestele, S. / Tessier, A. / Johnson, J.P. / Mantegazza, M. / Tytgat, J. / Cohen, C. / Beroud, R. / Bosmans, F. / Landon, C. / De Waard, M. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 108.3 KB | Display | ![]() |
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PDB format | ![]() | 89.9 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 432.7 KB | Display | ![]() |
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Full document | ![]() | 636.5 KB | Display | |
Data in XML | ![]() | 36.2 KB | Display | |
Data in CIF | ![]() | 30.4 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 8ciqC ![]() 8cjpC ![]() 8cjqC ![]() 8cjrC ![]() 8cjsC C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
Other databases |
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Links
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Assembly
Deposited unit | ![]()
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1 |
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NMR ensembles |
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Components
#1: Protein/peptide | Mass: 4048.675 Da / Num. of mol.: 1 / Mutation: W33A / Source method: obtained synthetically / Source: (synth.) ![]() |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||
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NMR experiment |
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Sample preparation
Details | Type: solution Contents: 0.1 mM unlabelled JzTx-34 W33A mutant (Jingzhaotoxin-34), 90% H2O/10% D2O Label: unlabelled / Solvent system: 90% H2O/10% D2O |
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Sample | Conc.: 0.1 mM / Component: JzTx-34 W33A mutant (Jingzhaotoxin-34) / Isotopic labeling: unlabelled |
Sample conditions | Ionic strength: 0 Not defined / Label: unlabelled / pH: 4.5 / Pressure: 1 atm / Temperature: 298 K |
-NMR measurement
NMR spectrometer | Type: Bruker AVANCE III HD / Manufacturer: Bruker / Model: AVANCE III HD / Field strength: 700 MHz / Details: cryoprobe |
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Processing
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Refinement | Method: molecular dynamics / Software ordinal: 1 | ||||||||||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 250 / Conformers submitted total number: 10 |