Entry | Database: PDB / ID: 8cfk |
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Title | Crystal structure of S-adenosyl-L-homocysteine hydrolase from P. aeruginosa in complex with F2X-Entry library fragment E06 |
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Components | Adenosylhomocysteinase |
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Keywords | HYDROLASE / Fragment screening / protein-ligand complex / drug discovery / SAM-DEPENDENT METHYLATION REACTIONS / SAHase / AHCY |
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Function / homology | Function and homology information
adenosylhomocysteinase / adenosylhomocysteinase activity / S-adenosylmethionine cycle / one-carbon metabolic process / cytosolSimilarity search - Function Adenosylhomocysteinase-like / S-adenosyl-L-homocysteine hydrolase, conserved site / Adenosylhomocysteinase-like superfamily / S-adenosyl-L-homocysteine hydrolase, NAD binding domain / S-adenosyl-L-homocysteine hydrolase / S-adenosyl-L-homocysteine hydrolase signature 1. / S-adenosyl-L-homocysteine hydrolase signature 2. / S-adenosyl-L-homocysteine hydrolase / S-adenosyl-L-homocysteine hydrolase, NAD binding domain / S-adenosyl-L-homocysteine hydrolase, NAD binding domain / NAD(P)-binding domain superfamilySimilarity search - Domain/homology ADENINE / : / NICOTINAMIDE-ADENINE-DINUCLEOTIDE / PHOSPHATE ION / (3-endo)-8-benzyl-8-azabicyclo[3.2.1]octan-3-ol / AdenosylhomocysteinaseSimilarity search - Component |
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Biological species | Pseudomonas aeruginosa PAO1 (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.73 Å |
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Authors | Malecki, P.H. / Gawel, M. / Stepniewska, M. / Brzezinski, K. |
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Funding support | Poland, 1items Organization | Grant number | Country |
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Polish National Science Centre | SONATA BIS 2018/30/E/NZ1/00729 | Poland |
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Citation | Journal: To be published Title: Crystal structure of S-adenosyl-L-homocysteine hydrolase from P. aeruginosa in complex with fragment F2X-Entry E06 Authors: Malecki, P.H. / Gawel, M. / Stepniewska, M. / Brzezinski, K. |
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History | Deposition | Feb 3, 2023 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Feb 21, 2024 | Provider: repository / Type: Initial release |
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