登録情報 | データベース: PDB / ID: 8cdg |
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タイトル | Crystal structure of human IL-17A cytokine in complex with macrocycle |
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要素 | Interleukin-17A |
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キーワード | CYTOKINE / inhibitor / complex / macrocycle |
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機能・相同性 | 機能・相同性情報
positive regulation of interleukin-16 production / granulocyte migration / positive regulation of antimicrobial peptide production / Interleukin-17 signaling / interleukin-17A-mediated signaling pathway / negative regulation of inflammatory response to wounding / intestinal epithelial structure maintenance / positive regulation of interleukin-23 production / cell death / positive regulation of chemokine (C-X-C motif) ligand 1 production ...positive regulation of interleukin-16 production / granulocyte migration / positive regulation of antimicrobial peptide production / Interleukin-17 signaling / interleukin-17A-mediated signaling pathway / negative regulation of inflammatory response to wounding / intestinal epithelial structure maintenance / positive regulation of interleukin-23 production / cell death / positive regulation of chemokine (C-X-C motif) ligand 1 production / interleukin-17-mediated signaling pathway / positive regulation of bicellular tight junction assembly / fibroblast activation / positive regulation of osteoclast differentiation / positive regulation of cytokine production involved in inflammatory response / keratinocyte proliferation / cellular response to interleukin-1 / defense response to fungus / keratinocyte differentiation / Notch signaling pathway / positive regulation of interleukin-12 production / positive regulation of interleukin-1 beta production / cytokine activity / positive regulation of interleukin-6 production / response to wounding / positive regulation of tumor necrosis factor production / cell-cell signaling / gene expression / Interleukin-4 and Interleukin-13 signaling / defense response to Gram-negative bacterium / adaptive immune response / defense response to Gram-positive bacterium / inflammatory response / immune response / protein heterodimerization activity / external side of plasma membrane / innate immune response / apoptotic process / SARS-CoV-2 activates/modulates innate and adaptive immune responses / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region類似検索 - 分子機能 Interleukin-17, chordata / Interleukin-17 family / Interleukin-17 / Cystine-knot cytokine類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.9 Å |
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データ登録者 | Schulze, M.-S. |
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資金援助 | 1件 |
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引用 | ジャーナル: Chem Sci / 年: 2023 タイトル: Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism. 著者: Shaw, D.J. / Waters, L.C. / Strong, S.L. / Schulze, M.E.D. / Greetham, G.M. / Towrie, M. / Parker, A.W. / Prosser, C.E. / Henry, A.J. / Lawson, A.D.G. / Carr, M.D. / Taylor, R.J. / Hunt, N.T. / Muskett, F.W. |
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履歴 | 登録 | 2023年1月30日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年12月6日 | Provider: repository / タイプ: Initial release |
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